OpenClaim

Lanadelumab Side Effects

The most commonly reported side effects of lanadelumab include hereditary angioedema, product dose omission issue, and weight decreased, based on 4,934 FDA adverse event reports from 2018 to 2025. 8.2% of reports found the drug to be ineffective.

Lanadelumab side effects

Percentages show how often each reaction appears relative to total reports for lanadelumab.

1
Hereditary Angioedema49.4%2,436
2
Product Dose Omission Issue16.2%799
3
Weight Decreased12.3%608
4
Weight Increased12.1%596
5
Inappropriate Schedule Of Product Administration10.1%500
6
Drug Ineffective8.2%403
7
Product Use Issue7.7%382
8
Injection Site Pain6.9%341
9
Covid-196.6%326
10
Headache5.9%293
11
Insurance Issue5.7%282
12
Stress5.6%278
13
Malaise4.4%216
14
Fall3.9%194
15
Off Label Use3.9%190

These are voluntary reports and do not establish that lanadelumab caused these reactions.

Report severity

65.0%Serious3,206 reports
36.8%Hospitalizations1,817 reports
3.0%Fatal148 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lanadelumab drug interactions

Other drugs that appear in adverse event reports alongside lanadelumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Icatibant-acetate29.9%1,474
2
Ecallantide3.7%184
3
Omalizumab1.0%48
4
Dupilumab1.0%47
5
Berotralstat-dihydrochloride0.8%38
6
Prednisone0.3%13
7
Levonorgestrel0.2%12
8
Rituximab0.2%11
9
Acetaminophen0.2%9
10
Dexamethasone0.2%8
11
Tranexamic-acid0.2%8
12
Letrozole0.2%8
13
Amoxicillin0.1%7
14
Ribociclib0.1%7
15
Denosumab0.1%7

Taken alongside

1
Epinephrine18.9%931
2
Icatibant-acetate15.6%770
3
Cetirizine-hydrochloride7.2%353
4
Albuterol7.1%351
5
Diphenhydramine6.9%339
6
Sodium-chloride6.6%328
7
Ergocalciferol6.5%321
8
Acetaminophen5.8%287
9
Heparin5.4%268
10
Ondansetron5.0%247
11
Famotidine4.9%241
12
Sterile4.6%228
13
Fluticasone4.6%225
14
Levothyroxine-sodium4.5%222
15
Gabapentin4.5%221

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lanadelumab side effects

58.0% of lanadelumab adverse event reports involve female patients and 17.8% involve male patients. The largest age group is adult at 79%. These figures reflect who reports side effects, not underlying risk.

Sex

Female58.0%
Male17.8%
Unknown24.2%

Age group

< 20.1%
2–111.8%
12–173.8%
18–6479.1%
65+15.2%

What is lanadelumab used for

Conditions and purposes for which patients were taking lanadelumab when the adverse event was reported.

AngioedemaAsthmaAbdominal DiscomfortAcquired C1 Inhibitor DeficiencyAcute SinusitisAdrenogenital SyndromeAlpha-1 Antitrypsin DeficiencyAnaemiaAnaphylactic ShockAngioedemaAnxiety DisorderAsthmaAutoimmune ThyroiditisBladder NeoplasmBreast Cancer Female

Showing 15 of 107 indications

Lanadelumab brand names and reporting trend

Lanadelumab is sold under the brand name Takhzyro.

Brand names

Takhzyro6,379

Quarterly reports (20182025)

20182020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lanadelumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.