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Lamotrigine Side Effects

The most commonly reported side effects of lamotrigine include seizure, off label use, and fatigue, based on 132,311 FDA adverse event reports from 2004 to 2025. 6.7% of reports found the drug to be ineffective.

Lamotrigine side effects

Percentages show how often each reaction appears relative to total reports for lamotrigine.

1
Drug Ineffective6.7%8,858
2
Seizure5.2%6,863
3
Off Label Use4.4%5,780
4
Fatigue3.8%5,081
5
Nausea3.8%4,983
6
Rash3.6%4,768
7
Dizziness3.5%4,642
8
Headache3.4%4,462
9
Toxicity To Various Agents3.1%4,146
10
Depression3.0%3,983
11
Rash2.9%3,814
12
Vomiting2.8%3,695
13
Anxiety2.7%3,588
14
Somnolence2.7%3,586
15
Foetal Exposure During Pregnancy2.7%3,523

These are voluntary reports and do not establish that lamotrigine caused these reactions.

Report severity

72.2%Serious95,489 reports
30.4%Hospitalizations40,263 reports
8.4%Fatal11,059 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lamotrigine drug interactions

Other drugs that appear in adverse event reports alongside lamotrigine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Levetiracetam7.8%10,286
2
Quetiapine-fumarate5.2%6,861
3
Topiramate3.9%5,132
4
Aripiprazole3.0%3,958
5
Lacosamide2.7%3,620
6
Sodium-oxybate2.6%3,408
7
Carbamazepine2.5%3,331
8
Valproic-acid2.4%3,218
9
Clonazepam2.3%2,995
10
Adalimumab2.2%2,965
11
Venlafaxine2.2%2,895
12
Acetaminophen2.2%2,893
13
Bupropion2.1%2,812
14
Clobazam2.0%2,677
15
Olanzapine2.0%2,670

Taken alongside

1
Clonazepam7.0%9,230
2
Levothyroxine-sodium6.2%8,237
3
Acetaminophen6.2%8,154
4
Ergocalciferol5.3%7,000
5
Gabapentin5.2%6,827
6
Quetiapine-fumarate4.8%6,297
7
Omeprazole4.3%5,749
8
Bupropion4.2%5,587
9
Lorazepam4.1%5,415
10
Levetiracetam4.1%5,403
11
Aspirin3.9%5,146
12
Albuterol3.9%5,114
13
Topiramate3.7%4,905
14
Trazodone-hydrochloride3.7%4,888
15
Duloxetine-hydrochloride3.5%4,615

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lamotrigine side effects

59.3% of lamotrigine adverse event reports involve female patients and 27.8% involve male patients. The largest age group is adult at 74%. These figures reflect who reports side effects, not underlying risk.

Sex

Female59.3%
Male27.8%
Unknown12.9%

Age group

< 23.6%
2–114.5%
12–175.6%
18–6474.0%
65+12.3%

What is lamotrigine used for

Conditions and purposes for which patients were taking lamotrigine when the adverse event was reported.

Abdominal DiscomfortAbdominal Pain UpperAbnormal BehaviourAbnormal DreamsAbsence SeizureAccidental Drug Intake By ChildAccidental ExposureAccidental Exposure To ProductAccidental Exposure To Product By ChildAccidental OverdoseAccidental PoisoningAcquired Epileptic AphasiaAcute Encephalitis With Refractory, Repetitive Partial SeizuresAcute PsychosisAdhd

Showing 15 of 1,102 indications

Lamotrigine brand names and reporting trend

Lamotrigine is sold under the brand name Lamictal Cd.

Brand names

Lamictal Cd87,522

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lamotrigine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.