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Lamivudine Side Effects

The most commonly reported side effects of lamivudine include foetal exposure during pregnancy, pain, and virologic failure, based on 54,338 FDA adverse event reports from 2004 to 2025. 2.7% of reports found the drug to be ineffective.

Lamivudine side effects

Percentages show how often each reaction appears relative to total reports for lamivudine.

1
Foetal Exposure During Pregnancy5.9%3,226
2
Pain4.4%2,406
3
Virologic Failure4.3%2,312
4
Pathogen Resistance3.8%2,084
5
Anxiety3.8%2,061
6
Drug Resistance3.7%1,987
7
Viral Mutation Identified3.6%1,954
8
Product Dose Omission Issue3.5%1,922
9
Drug Exposure During Pregnancy3.5%1,878
10
Drug Interaction3.5%1,877
11
Exposure During Pregnancy3.3%1,799
12
Depression3.3%1,778
13
Emotional Distress3.3%1,771
14
Anhedonia2.9%1,586
15
Drug Ineffective2.7%1,472

These are voluntary reports and do not establish that lamivudine caused these reactions.

Report severity

85.2%Serious46,320 reports
26.9%Hospitalizations14,596 reports
10.4%Fatal5,661 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lamivudine drug interactions

Other drugs that appear in adverse event reports alongside lamivudine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Zidovudine23.7%12,856
2
Abacavir23.4%12,697
3
Tenofovir22.4%12,157
4
Dolutegravir20.7%11,261
5
Ritonavir20.2%10,958
6
Efavirenz14.9%8,121
7
Nevirapine12.0%6,504
8
Lopinavir11.0%5,970
9
Emtricitabine9.0%4,915
10
Stavudine7.4%4,045
11
Atazanavir-sulfate6.5%3,545
12
Raltegravir-potassium6.5%3,537
13
Darunavir4.8%2,607
14
Didanosine4.0%2,191
15
Nelfinavir-mesylate3.5%1,878

Taken alongside

1
Abacavir9.6%5,229
2
Ritonavir8.8%4,772
3
Tenofovir7.9%4,289
4
Zidovudine7.9%4,274
5
Dolutegravir6.1%3,320
6
Sulfamethoxazole4.4%2,403
7
Emtricitabine4.3%2,361
8
Efavirenz4.2%2,263
9
Lopinavir3.9%2,122
10
Trimethoprim3.8%2,083
11
Raltegravir-potassium3.3%1,799
12
Acetaminophen3.1%1,682
13
Atazanavir-sulfate3.0%1,655
14
Darunavir2.8%1,524
15
Aspirin2.7%1,463

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lamivudine side effects

30.2% of lamivudine adverse event reports involve female patients and 49.2% involve male patients. The largest age group is adult at 81%. These figures reflect who reports side effects, not underlying risk.

Sex

Female30.2%
Male49.2%
Unknown20.6%

Age group

< 26.0%
2–112.1%
12–171.5%
18–6481.3%
65+9.0%

What is lamivudine used for

Conditions and purposes for which patients were taking lamivudine when the adverse event was reported.

Accidental ExposureAccidental Exposure To ProductAccidental Needle StickAcquired Immune Deficiency SyndromeAcquired Immunodeficiency SyndromeAcute Hepatitis BAcute Hiv InfectionAcute On Chronic Liver FailureAdult T-cell Lymphoma/leukaemiaAdverse EventAicardi^s SyndromeAids Related ComplicationAlanine Aminotransferase IncreasedAnal CancerAntibiotic Prophylaxis

Showing 15 of 403 indications

Lamivudine brand names and reporting trend

Lamivudine is sold under brand names including Lamivudine/nevirapine/zidovudine Tablets, Lamivudine, Nevirapine, And Stavudine.

Brand names

Lamivudine/nevirapine/zidovudine Tablets31,015
Lamivudine, Nevirapine, And Stavudine44

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lamivudine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.