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Lacosamide Side Effects

The most commonly reported side effects of lacosamide include seizure, off label use, and dizziness, based on 35,697 FDA adverse event reports from 2008 to 2025. 10.8% of reports found the drug to be ineffective.

Lacosamide side effects

Percentages show how often each reaction appears relative to total reports for lacosamide.

1
Seizure18.3%6,542
2
Drug Ineffective10.8%3,862
3
Off Label Use10.4%3,720
4
Dizziness4.1%1,449
5
Somnolence3.7%1,330
6
Epilepsy3.6%1,295
7
Fatigue3.6%1,289
8
Fall3.6%1,278
9
Overdose3.4%1,197
10
Status Epilepticus3.2%1,154
11
Generalised Tonic-clonic Seizure3.2%1,135
12
Death2.8%1,015
13
Headache2.7%960
14
Drug Interaction2.5%875
15
Nausea2.3%813

These are voluntary reports and do not establish that lacosamide caused these reactions.

Report severity

79.0%Serious28,186 reports
34.2%Hospitalizations12,203 reports
8.5%Fatal3,047 reports

Seriousness is determined by the reporter, not by OpenClaim.

Lacosamide drug interactions

Other drugs that appear in adverse event reports alongside lacosamide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Levetiracetam28.8%10,265
2
Lamotrigine7.0%2,512
3
Phenytoin6.0%2,151
4
Clobazam5.6%1,997
5
Topiramate5.1%1,831
6
Valproic-acid4.7%1,669
7
Brivaracetam4.4%1,573
8
Carbamazepine4.0%1,431
9
Cannabidiol4.0%1,425
10
Perampanel4.0%1,412
11
Phenobarbital-sodium3.9%1,407
12
Midazolam3.9%1,399
13
Oxcarbazepine3.3%1,167
14
Zonisamide2.7%962
15
Cenobamate2.7%958

Taken alongside

1
Levetiracetam14.6%5,200
2
Lamotrigine7.4%2,647
3
Clobazam6.2%2,229
4
Clonazepam5.4%1,925
5
Topiramate5.2%1,871
6
Acetaminophen4.5%1,623
7
Lorazepam4.2%1,499
8
Phenytoin4.1%1,462
9
Carbamazepine4.0%1,434
10
Ergocalciferol3.9%1,401
11
Levothyroxine-sodium3.6%1,301
12
Diazepam3.5%1,237
13
Aspirin3.4%1,205
14
Oxcarbazepine3.3%1,191
15
Gabapentin3.2%1,153

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports lacosamide side effects

46.0% of lacosamide adverse event reports involve female patients and 37.8% involve male patients. The largest age group is adult at 61%. These figures reflect who reports side effects, not underlying risk.

Sex

Female46.0%
Male37.8%
Unknown16.2%

Age group

< 23.8%
2–118.0%
12–175.2%
18–6460.6%
65+22.3%

What is lacosamide used for

Conditions and purposes for which patients were taking lacosamide when the adverse event was reported.

Adjuvant TherapyAffective DisorderAltered State Of ConsciousnessAmnesiaAnalgesic TherapyAnticonvulsant Drug LevelAnticonvulsant Drug Level Below TherapeuticApnoeaApnoeic AttackArteriovenous MalformationAstrocytomaAtonic SeizuresAtrial FibrillationAttention Deficit Hyperactivity DisorderAtypical Benign Partial Epilepsy

Showing 15 of 513 indications

Lacosamide brand names and reporting trend

Lacosamide is sold under the brand name Vimpat.

Brand names

Vimpat23,994

Quarterly reports (20082025)

2010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking lacosamide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.