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Ixekizumab Side Effects

The most commonly reported side effects of ixekizumab include injection site pain, psoriasis, and injection site erythema, based on 35,924 FDA adverse event reports from 2016 to 2025. 8.8% of reports found the drug to be ineffective.

Ixekizumab side effects

Percentages show how often each reaction appears relative to total reports for ixekizumab.

1
Injection Site Pain10.7%3,854
2
Drug Ineffective8.8%3,179
3
Psoriasis8.8%3,159
4
Injection Site Erythema6.0%2,168
5
Injection Site Reaction4.9%1,750
6
Injection Site Swelling4.5%1,626
7
Incorrect Dose Administered3.1%1,120
8
Product Dose Omission Issue2.6%932
9
Covid-192.6%918
10
Pain2.4%876
11
Arthralgia2.4%862
12
Therapy Interrupted2.3%816
13
Diarrhoea2.2%808
14
Rash2.2%794
15
Injection Site Pruritus2.2%782

These are voluntary reports and do not establish that ixekizumab caused these reactions.

Report severity

20.9%Serious7,512 reports
7.9%Hospitalizations2,828 reports
1.5%Fatal529 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ixekizumab drug interactions

Other drugs that appear in adverse event reports alongside ixekizumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Secukinumab3.3%1,202
2
Adalimumab3.1%1,098
3
Methotrexate2.7%970
4
Etanercept2.0%723
5
Apremilast1.7%617
6
Certolizumab-pegol1.1%380
7
Ustekinumab1.0%356
8
Infliximab1.0%349
9
Sulfasalazine0.7%250
10
Golimumab0.6%232
11
Leflunomide0.6%222
12
Tofacitinib0.6%219
13
Guselkumab0.6%216
14
Risankizumab-rzaa0.6%209
15
Dupilumab0.5%184

Taken alongside

1
Methotrexate1.6%579
2
Prednisone1.4%520
3
Adalimumab1.2%428
4
Metformin0.9%337
5
Ergocalciferol0.9%324
6
Folic-acid0.9%317
7
Omeprazole0.9%312
8
Acetaminophen0.8%296
9
Levothyroxine-sodium0.8%293
10
Secukinumab0.8%283
11
Clobetasol-propionate0.7%253
12
Atorvastatin-calcium0.7%247
13
Etanercept0.7%243
14
Apremilast0.6%225
15
Aspirin0.6%217

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ixekizumab side effects

55.6% of ixekizumab adverse event reports involve female patients and 35.6% involve male patients. The largest age group is adult at 81%. These figures reflect who reports side effects, not underlying risk.

Sex

Female55.6%
Male35.6%
Unknown8.9%

Age group

< 20.2%
2–110.6%
12–171.3%
18–6480.5%
65+17.5%

What is ixekizumab used for

Conditions and purposes for which patients were taking ixekizumab when the adverse event was reported.

AcneAnkylosing SpondylitisAnxietyArachnoiditisArthralgiaArthritisArthropathyAsthmaAutoimmune DisorderAxial SpondyloarthritisAcneAdverse Drug ReactionAlopecia ScarringAndrogenetic AlopeciaAnkylosing Spondylitis

Showing 15 of 217 indications

Ixekizumab brand names and reporting trend

Ixekizumab is sold under the brand name Taltz.

Brand names

Taltz1,751

Quarterly reports (20162025)

2016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ixekizumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.