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Ixazomib Side Effects

The most commonly reported side effects of ixazomib include plasma cell myeloma, death, and diarrhoea, based on 28,522 FDA adverse event reports from 2015 to 2025. 2.8% of reports found the drug to be ineffective.

Ixazomib side effects

Percentages show how often each reaction appears relative to total reports for ixazomib.

1
Plasma Cell Myeloma12.8%3,650
2
Death11.6%3,299
3
Diarrhoea11.0%3,149
4
Off Label Use10.4%2,977
5
Pneumonia6.8%1,937
6
Fatigue6.7%1,917
7
Nausea6.5%1,843
8
Neuropathy Peripheral5.1%1,452
9
Vomiting3.9%1,109
10
Rash3.8%1,086
11
Thrombocytopenia3.7%1,048
12
Platelet Count Decreased3.6%1,015
13
Constipation3.4%968
14
Asthenia3.2%913
15
Product Dose Omission Issue2.8%799

These are voluntary reports and do not establish that ixazomib caused these reactions.

Report severity

74.3%Serious21,187 reports
30.6%Hospitalizations8,737 reports
18.5%Fatal5,270 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ixazomib drug interactions

Other drugs that appear in adverse event reports alongside ixazomib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lenalidomide42.0%11,977
2
Dexamethasone33.1%9,454
3
Pomalidomide13.2%3,768
4
Bortezomib4.2%1,192
5
Cyclophosphamide4.1%1,173
6
Daratumumab3.5%1,004
7
Thalidomide1.6%470
8
Carfilzomib1.4%408
9
Acyclovir1.1%326
10
Doxorubicin-hydrochloride0.9%257
11
Melphalan0.8%234
12
Prednisone0.8%219
13
Amoxicillin0.6%169
14
Selinexor0.6%159
15
Etoposide0.5%131

Taken alongside

1
Dexamethasone19.9%5,669
2
Acyclovir17.3%4,948
3
Aspirin14.0%4,000
4
Lenalidomide9.3%2,666
5
Ergocalciferol7.4%2,109
6
Acetaminophen7.0%1,985
7
Ondansetron6.0%1,713
8
Omeprazole5.2%1,470
9
Gabapentin4.9%1,392
10
Pantoprazole-sodium4.8%1,377
11
Amlodipine4.7%1,338
12
Metoprolol4.2%1,195
13
Furosemide4.1%1,170
14
Levothyroxine-sodium4.0%1,144
15
Atorvastatin-calcium3.9%1,126

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ixazomib side effects

45.3% of ixazomib adverse event reports involve female patients and 49.6% involve male patients. The largest age group is elderly at 72%. These figures reflect who reports side effects, not underlying risk.

Sex

Female45.3%
Male49.6%
Unknown5.1%

Age group

< 2<0.1%
2–11<0.1%
12–17<0.1%
18–6428.3%
65+71.6%

What is ixazomib used for

Conditions and purposes for which patients were taking ixazomib when the adverse event was reported.

Acute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Lymphocytic Leukaemia RefractoryAcute Monocytic Leukaemia (in Remission)Acute Myeloid LeukaemiaAcute Myeloid Leukaemia RefractoryAdjuvant TherapyAdverse EventAmyloidosisAnaemiaAngioimmunoblastic T-cell LymphomaAplastic AnaemiaAsymptomatic Hiv InfectionAcute Hepatic FailureAcute Lymphocytic Leukaemia

Showing 15 of 251 indications

Ixazomib brand names and reporting trend

Ixazomib is sold under the brand name Ninlaro.

Brand names

Ninlaro16,732

Quarterly reports (20152025)

2016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ixazomib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.