OpenClaim

Ivabradine Side Effects

The most commonly reported side effects of ivabradine include off label use, dyspnoea, and hypotension, based on 7,473 FDA adverse event reports from 2006 to 2025. 4.4% of reports found the drug to be ineffective.

Ivabradine side effects

Percentages show how often each reaction appears relative to total reports for ivabradine.

1
Off Label Use18.0%1,342
2
Dyspnoea7.5%563
3
Hypotension6.1%458
4
Cardiac Failure5.3%397
5
Dizziness5.1%384
6
Fatigue4.6%345
7
Drug Interaction4.5%338
8
Drug Ineffective4.4%332
9
Bradycardia3.8%284
10
Nausea3.7%277
11
Headache3.6%266
12
Chest Pain3.0%221
13
Malaise2.7%202
14
Death2.6%192
15
Palpitations2.5%190

These are voluntary reports and do not establish that ivabradine caused these reactions.

Report severity

74.7%Serious5,585 reports
38.8%Hospitalizations2,896 reports
8.3%Fatal623 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ivabradine drug interactions

Other drugs that appear in adverse event reports alongside ivabradine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sacubitril6.8%505
2
Valsartan6.7%501
3
Furosemide6.5%484
4
Ramipril5.8%432
5
Bisoprolol-fumarate5.2%391
6
Aspirin4.6%344
7
Spironolactone4.4%326
8
Carvedilol3.8%282
9
Atorvastatin-calcium3.3%246
10
Eplerenone3.3%244
11
Metformin2.9%217
12
Metoprolol2.7%201
13
Rosuvastatin2.6%192
14
Dapagliflozin2.1%155
15
Pantoprazole-sodium2.0%153

Taken alongside

1
Aspirin15.8%1,181
2
Furosemide14.0%1,048
3
Atorvastatin-calcium13.2%984
4
Bisoprolol-fumarate9.9%737
5
Spironolactone9.4%704
6
Albuterol8.2%615
7
Acetaminophen8.0%595
8
Omeprazole7.5%561
9
Pantoprazole-sodium7.4%550
10
Metformin7.1%531
11
Carvedilol6.4%482
12
Levothyroxine-sodium6.0%451
13
Metoprolol5.8%436
14
Gemfibrozil5.7%423
15
Ramipril5.4%404

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ivabradine side effects

48.6% of ivabradine adverse event reports involve female patients and 37.3% involve male patients. The largest age group is adult at 59%. These figures reflect who reports side effects, not underlying risk.

Sex

Female48.6%
Male37.3%
Unknown14.1%

Age group

< 21.1%
2–110.4%
12–171.4%
18–6459.0%
65+38.1%

What is ivabradine used for

Conditions and purposes for which patients were taking ivabradine when the adverse event was reported.

Abdominal DiscomfortAcute Coronary SyndromeAcute Left Ventricular FailureAcute Myocardial InfarctionAdverse EventAlcohol UseAngina PectorisAngina UnstableAnxietyArrhythmiaArrhythmia ProphylaxisArrhythmia SupraventricularArteriosclerosisArteriosclerosis Coronary ArteryArteriospasm Coronary

Showing 15 of 280 indications

Ivabradine brand names and reporting trend

Ivabradine is sold under brand names including Corlanor, Ivabradine Hydrochloride.

Brand names

Corlanor6,024
Ivabradine Hydrochloride64

Quarterly reports (20062025)

20062010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ivabradine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.