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Isoflurane Side Effects

The most commonly reported side effects of isoflurane include hyperthermia malignant, hypotension, and renal failure, based on 2,261 FDA adverse event reports from 2004 to 2025. 7.1% of reports found the drug to be ineffective.

Isoflurane side effects

Percentages show how often each reaction appears relative to total reports for isoflurane.

1
Hyperthermia Malignant11.5%260
2
Hypotension7.3%164
3
Drug Ineffective7.1%160
4
Renal Failure6.1%138
5
Pain6.0%136
6
Injury5.8%131
7
Unevaluable Event5.4%122
8
Anxiety5.4%121
9
Off Label Use4.7%107
10
Fear4.7%106
11
Emotional Distress4.3%98
12
Renal Injury4.2%94
13
Renal Impairment4.0%90
14
Anhedonia3.9%89
15
Intestinal Ischaemia3.8%85

These are voluntary reports and do not establish that isoflurane caused these reactions.

Report severity

94.2%Serious2,129 reports
33.0%Hospitalizations747 reports
14.0%Fatal317 reports

Seriousness is determined by the reporter, not by OpenClaim.

Isoflurane drug interactions

Other drugs that appear in adverse event reports alongside isoflurane. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Propofol25.8%583
2
Fentanyl15.7%355
3
Midazolam13.8%313
4
Succinylcholine-chloride9.2%209
5
Aprotinin7.6%171
6
Ketamine-hydrochloride7.3%166
7
Lidocaine6.6%149
8
Phenytoin6.4%145
9
Valproic-acid6.3%143
10
Levetiracetam6.1%138
11
Vecuronium-bromide5.0%114
12
Nitrous-oxide4.9%110
13
Sevoflurane4.7%106
14
Phenobarbital-sodium4.6%104
15
Rocuronium-bromide4.4%100

Taken alongside

1
Fentanyl27.0%611
2
Propofol21.9%496
3
Midazolam17.4%394
4
Heparin9.6%217
5
Lidocaine9.4%213
6
Oxygen8.9%201
7
Nitrous-oxide8.8%198
8
Vecuronium-bromide8.5%192
9
Rocuronium-bromide7.9%179
10
Furosemide6.9%157
11
Cefazolin-sodium6.9%155
12
Acetaminophen6.5%147
13
Pancuronium-bromide6.5%146
14
Thiopental-sodium6.2%140
15
Epinephrine5.8%132

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports isoflurane side effects

39.2% of isoflurane adverse event reports involve female patients and 36.4% involve male patients. The largest age group is adult at 65%. These figures reflect who reports side effects, not underlying risk.

Sex

Female39.2%
Male36.4%
Unknown24.4%

Age group

< 24.2%
2–117.5%
12–175.1%
18–6464.8%
65+18.4%

What is isoflurane used for

Conditions and purposes for which patients were taking isoflurane when the adverse event was reported.

Accidental ExposureAccidental Exposure To ProductAddison's DiseaseAnaesthesiaAnaesthesia ProcedureAnaesthesia ReversalAnalgesic TherapyAnesthesiaAntibiotic ProphylaxisAortic SurgeryAsthmaAdverse Drug ReactionAnaesthesiaAnaesthesia ProcedureAortic Valve Replacement

Showing 15 of 118 indications

Isoflurane brand names and reporting trend

Isoflurane is sold under the brand name Isoflurane.

Brand names

Isoflurane1,845

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking isoflurane with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.