OpenClaim

Isocarboxazid Side Effects

The most commonly reported side effects of isocarboxazid include completed suicide, toxicity to various agents, and insomnia, based on 77 FDA adverse event reports from 2004 to 2025. 9.1% of reports found the drug to be ineffective.

Isocarboxazid side effects

Percentages show how often each reaction appears relative to total reports for isocarboxazid.

1
Completed Suicide19.5%15
2
Toxicity To Various Agents9.1%7
3
Drug Ineffective9.1%7
4
Insomnia6.5%5
5
Dizziness6.5%5
6
Vision Blurred5.2%4
7
Weight Increased5.2%4
8
Muscle Twitching5.2%4
9
Serotonin Syndrome5.2%4
10
Insomnia5.2%4
11
Drug Ineffective3.9%3
12
Blood Pressure Increased3.9%3
13
Nervousness3.9%3
14
Stress Cardiomyopathy3.9%3
15
Stress Cardiomyopathy3.9%3

These are voluntary reports and do not establish that isocarboxazid caused these reactions.

Report severity

76.6%Serious59 reports
35.1%Hospitalizations27 reports
24.7%Fatal19 reports

Seriousness is determined by the reporter, not by OpenClaim.

Isocarboxazid drug interactions

Other drugs that appear in adverse event reports alongside isocarboxazid. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lamotrigine27.3%21
2
Quetiapine-fumarate23.4%18
3
Diazepam20.8%16
4
Bupropion19.5%15
5
Citalopram-hydrobromide19.5%15
6
Lurasidone-hydrochloride19.5%15
7
Lithium7.8%6
8
Phenelzine-sulfate6.5%5
9
Tranylcypromine-sulfate3.9%3
10
Dabigatran-etexilate-mesylate3.9%3
11
Rivaroxaban3.9%3
12
Aripiprazole3.9%3
13
Simvastatin2.6%2
14
Olanzapine2.6%2
15
Albuterol2.6%2

Taken alongside

1
Lorazepam6.5%5
2
Aspirin6.5%5
3
Metformin6.5%5
4
Amlodipine5.2%4
5
Levothyroxine-sodium5.2%4
6
Furosemide3.9%3
7
Atenolol3.9%3
8
Diazepam3.9%3
9
Diclofenac3.9%3
10
Lansoprazole3.9%3
11
Fluticasone3.9%3
12
Lithium3.9%3
13
Albuterol3.9%3
14
Terbutaline-sulfate3.9%3
15
Lamotrigine3.9%3

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports isocarboxazid side effects

67.5% of isocarboxazid adverse event reports involve female patients and 24.7% involve male patients. The largest age group is adult at 70%. These figures reflect who reports side effects, not underlying risk.

Sex

Female67.5%
Male24.7%
Unknown7.8%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6470.2%
65+29.8%

What is isocarboxazid used for

Conditions and purposes for which patients were taking isocarboxazid when the adverse event was reported.

Antidepressant TherapyAnxietyBipolar DisorderBipolar DisorderDepressionDrug Use For Unknown IndicationElectrolyte Substitution TherapyMajor DepressionProduct Used For Unknown IndicationProduct Used For Unknown Indication

Isocarboxazid brand names and reporting trend

Isocarboxazid is sold under the brand name Marplan.

Brand names

Marplan45

Quarterly reports (20042025)

200520152025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking isocarboxazid with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.