OpenClaim

Isavuconazonium Side Effects

The most commonly reported side effects of isavuconazonium include off label use, death, and nausea, based on 3,413 FDA adverse event reports from 2015 to 2025. 4.5% of reports found the drug to be ineffective.

Isavuconazonium side effects

Percentages show how often each reaction appears relative to total reports for isavuconazonium.

1
Off Label Use28.0%957
2
Death9.2%314
3
Drug Ineffective4.5%154
4
Nausea4.4%151
5
Febrile Neutropenia4.4%149
6
Pyrexia4.0%137
7
Pneumonia3.6%124
8
Condition Aggravated3.3%111
9
Fatigue3.0%102
10
Diarrhoea2.9%98
11
Dyspnoea2.8%96
12
Product Use In Unapproved Indication2.7%92
13
Drug Interaction2.6%90
14
Vomiting2.5%86
15
Acute Kidney Injury2.3%77

These are voluntary reports and do not establish that isavuconazonium caused these reactions.

Report severity

69.0%Serious2,355 reports
33.5%Hospitalizations1,142 reports
20.7%Fatal706 reports

Seriousness is determined by the reporter, not by OpenClaim.

Isavuconazonium drug interactions

Other drugs that appear in adverse event reports alongside isavuconazonium. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Venetoclax7.1%244
2
Amphotericin-b5.6%191
3
Voriconazole4.9%168
4
Ruxolitinib4.7%161
5
Tacrolimus2.6%90
6
Vancomycin2.5%85
7
Meropenem2.5%85
8
Prednisone2.3%77
9
Posaconazole2.2%75
10
Cytarabine2.1%73
11
Azacitidine2.0%69
12
Cyclophosphamide2.0%68
13
Belumosudil-mesylate1.9%64
14
Caspofungin-acetate1.8%61
15
Acyclovir1.6%56

Taken alongside

1
Acyclovir20.7%705
2
Pantoprazole-sodium11.4%388
3
Prednisone11.1%379
4
Ondansetron10.2%349
5
Levofloxacin9.2%313
6
Acetaminophen8.8%299
7
Ergocalciferol8.7%298
8
Tacrolimus8.1%278
9
Sulfamethoxazole7.5%255
10
Trimethoprim7.2%246
11
Furosemide6.2%212
12
Ursodiol6.2%211
13
Albuterol5.9%201
14
Allopurinol5.9%201
15
Metoprolol5.8%197

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports isavuconazonium side effects

36.0% of isavuconazonium adverse event reports involve female patients and 53.7% involve male patients. The largest age group is adult at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female36.0%
Male53.7%
Unknown10.3%

Age group

< 2<0.1%
2–111.7%
12–173.2%
18–6454.2%
65+40.8%

What is isavuconazonium used for

Conditions and purposes for which patients were taking isavuconazonium when the adverse event was reported.

Acute EndocarditisAcute LeukaemiaAcute Lymphocytic LeukaemiaAcute Megakaryocytic LeukaemiaAcute Monocytic LeukaemiaAcute Myeloid LeukaemiaAcute Myeloid Leukaemia (in Remission)Acute Promyelocytic LeukaemiaAcute Pulmonary HistoplasmosisAcute SinusitisAdrenal DisorderAdverse Drug ReactionAgranulocytosisAllescheriosisAllogenic Bone Marrow Transplantation Therapy

Showing 15 of 341 indications

Isavuconazonium brand names and reporting trend

Isavuconazonium is sold under the brand name Cresemba.

Brand names

Cresemba675

Quarterly reports (20152025)

2016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking isavuconazonium with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.