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Ipilimumab Side Effects

The most commonly reported side effects of ipilimumab include death, malignant neoplasm progression, and diarrhoea, based on 41,655 FDA adverse event reports from 2006 to 2025.

Ipilimumab side effects

Percentages show how often each reaction appears relative to total reports for ipilimumab.

1
Death9.7%4,045
2
Malignant Neoplasm Progression8.8%3,679
3
Diarrhoea7.0%2,906
4
Off Label Use5.7%2,371
5
Colitis5.3%2,205
6
Pyrexia4.7%1,958
7
Rash4.1%1,714
8
Fatigue3.9%1,608
9
Intentional Product Use Issue3.2%1,349
10
Nausea3.1%1,298
11
Decreased Appetite2.5%1,054
12
Hypophysitis2.5%1,050
13
Immune-mediated Enterocolitis2.5%1,030
14
Vomiting2.4%987
15
Dyspnoea2.3%970

These are voluntary reports and do not establish that ipilimumab caused these reactions.

Report severity

88.8%Serious36,999 reports
45.8%Hospitalizations19,070 reports
22.2%Fatal9,240 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ipilimumab drug interactions

Other drugs that appear in adverse event reports alongside ipilimumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Nivolumab68.5%28,542
2
Carboplatin5.6%2,315
3
Paclitaxel2.7%1,105
4
Pembrolizumab2.6%1,067
5
Pemetrexed2.4%996
6
Cabozantinib1.8%762
7
Prednisone1.0%425
8
Cisplatin1.0%418
9
Trametinib1.0%406
10
Dabrafenib-mesylate0.9%378
11
Methylprednisolone0.8%348
12
Bevacizumab0.8%316
13
Prednisolone0.7%306
14
Binimetinib0.7%306
15
Encorafenib0.7%297

Taken alongside

1
Acetaminophen5.3%2,218
2
Levothyroxine-sodium3.7%1,554
3
Prednisone3.4%1,399
4
Pantoprazole-sodium3.2%1,352
5
Aspirin3.2%1,348
6
Ondansetron3.2%1,329
7
Amlodipine3.0%1,247
8
Omeprazole3.0%1,234
9
Oxycodone2.8%1,175
10
Dexamethasone2.6%1,076
11
Atorvastatin-calcium2.5%1,039
12
Metformin2.0%844
13
Nivolumab2.0%829
14
Prednisolone1.9%801
15
Hydrocortisone1.9%800

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ipilimumab side effects

30.6% of ipilimumab adverse event reports involve female patients and 54.8% involve male patients. The largest age group is elderly at 50%. These figures reflect who reports side effects, not underlying risk.

Sex

Female30.6%
Male54.8%
Unknown14.6%

Age group

< 2<0.1%
2–110.1%
12–170.2%
18–6449.6%
65+50.1%

What is ipilimumab used for

Conditions and purposes for which patients were taking ipilimumab when the adverse event was reported.

Abdominal NeoplasmAcral Lentiginous MelanomaAcral Lentiginous Melanoma Stage IvActinic ElastosisActinic KeratosisAcute Kidney InjuryAcute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAcute Myeloid Leukaemia RecurrentAdenocarcinomaAdenocarcinoma GastricAdenocarcinoma MetastaticAdenocarcinoma Of AppendixAdenocarcinoma Of ColonAdenocarcinoma Of The Cervix

Showing 15 of 848 indications

Ipilimumab brand names and reporting trend

Ipilimumab is sold under the brand name Yervoy.

Brand names

Yervoy23,127

Quarterly reports (20062025)

20062010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ipilimumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.