OpenClaim

Iodine Side Effects

The most commonly reported side effects of iodine include skin irritation, thermal burn, and blister, based on 185 FDA adverse event reports from 2004 to 2025.

Iodine side effects

Percentages show how often each reaction appears relative to total reports for iodine.

1
Skin Irritation18.4%34
2
Thermal Burn15.1%28
3
Blister13.5%25
4
Skin Reaction8.1%15
5
Pruritus7.6%14
6
Rash6.5%12
7
Excoriation5.4%10
8
Caustic Injury4.9%9
9
Skin Disorder4.9%9
10
Blister4.9%9
11
Thermal Burn4.9%9
12
Application Site Reaction4.3%8
13
Skin Exfoliation3.8%7
14
Rash3.8%7
15
Wound3.8%7

These are voluntary reports and do not establish that iodine caused these reactions.

Report severity

73.0%Serious135 reports
3.8%Hospitalizations7 reports
0.0%Fatal0 reports

Seriousness is determined by the reporter, not by OpenClaim.

Iodine drug interactions

Other drugs that appear in adverse event reports alongside iodine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Isopropyl-alcohol98.9%183
2
Chlorhexidine-gluconate5.4%10
3
Hexachlorophene0.5%1
4
Cefazolin-sodium0.5%1
5
Lidocaine0.5%1
6
Diltiazem0.5%1
7
Midazolam0.5%1
8
Bacitracin0.5%1
9
Pimozide0.5%1
10
Vancomycin0.5%1
11
Pseudoephedrine0.5%1
12
Cefuroxime0.5%1
13
Phenylephrine0.5%1
14
Onabotulinumtoxina0.5%1
15
Bupivacaine0.5%1

Taken alongside

1
Alcohol2.2%4
2
Chlorhexidine-gluconate1.6%3
3
Isopropyl-alcohol1.6%3
4
Levothyroxine-sodium1.6%3
5
Oxycodone1.6%3
6
Aspirin1.1%2
7
Povidone-iodine1.1%2
8
Ergocalciferol1.1%2
9
Bupropion1.1%2
10
Clopidogrel-bisulfate0.5%1
11
Oxygen0.5%1
12
Hexachlorophene0.5%1
13
Atenolol0.5%1
14
Morphine-sulfate0.5%1
15
Loratadine0.5%1

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports iodine side effects

44.9% of iodine adverse event reports involve female patients and 26.5% involve male patients. The largest age group is adult at 67%. These figures reflect who reports side effects, not underlying risk.

Sex

Female44.9%
Male26.5%
Unknown28.6%

Age group

< 21.6%
2–110.0%
12–171.6%
18–6467.2%
65+29.5%

What is iodine used for

Conditions and purposes for which patients were taking iodine when the adverse event was reported.

Antibiotic ProphylaxisArteriovenous Fistula OperationCardiac Pacemaker InsertionInfection ProphylaxisInfection ProphylaxisPreoperative CareProduct Used For Unknown IndicationPreoperative CareSkin DisorderSurgerySurgical PreconditioningTherapeutic Skin Care Topical

Iodine brand names and reporting trend

Iodine is sold under the brand name Duraprep.

Brand names

Duraprep1

Quarterly reports (20042025)

2004201020202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking iodine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.