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Inotersen Side Effects

The most commonly reported side effects of inotersen include platelet count decreased, protein urine present, and glomerular filtration rate decreased, based on 1,747 FDA adverse event reports from 2016 to 2025.

Inotersen side effects

Percentages show how often each reaction appears relative to total reports for inotersen.

1
Platelet Count Decreased19.2%335
2
Protein Urine Present15.4%269
3
Glomerular Filtration Rate Decreased15.1%264
4
Urine Protein/creatinine Ratio Increased14.3%249
5
Blood Creatinine Increased12.2%214
6
Fatigue11.4%200
7
Bacterial Test Positive11.0%193
8
Urine Abnormality10.6%185
9
Nausea8.8%153
10
Malaise8.3%145
11
Asthenia8.0%140
12
Diarrhoea7.8%137
13
Urinary Casts7.3%127
14
White Blood Cells Urine Positive7.2%125
15
Pain7.1%124

These are voluntary reports and do not establish that inotersen caused these reactions.

Report severity

67.4%Serious1,178 reports
33.3%Hospitalizations581 reports
7.4%Fatal129 reports

Seriousness is determined by the reporter, not by OpenClaim.

Inotersen drug interactions

Other drugs that appear in adverse event reports alongside inotersen. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Tafamidis0.6%11
2
Furosemide0.5%8
3
Pregabalin0.4%7
4
Clarithromycin0.4%7
5
Patisiran-sodium0.3%6
6
Nitrofurantoin0.3%6
7
Isosorbide0.3%6
8
Dapagliflozin0.3%6
9
Atorvastatin-calcium0.3%5
10
Midodrine-hydrochloride0.3%5
11
Duloxetine-hydrochloride0.2%4
12
Loperamide-hydrochloride0.2%4
13
Prednisone0.2%4
14
Mirtazapine0.2%4
15
Pantoprazole-sodium0.2%4

Taken alongside

1
Furosemide13.8%241
2
Aspirin11.2%196
3
Pregabalin9.7%169
4
Spironolactone8.7%152
5
Atorvastatin-calcium8.5%149
6
Gabapentin8.1%142
7
Acetaminophen7.4%129
8
Apixaban6.6%116
9
Ergocalciferol6.3%110
10
Vitamin-a6.0%105
11
Metoprolol5.7%100
12
Tafamidis5.6%98
13
Pantoprazole-sodium5.4%95
14
Levothyroxine-sodium5.4%94
15
Omeprazole5.3%92

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports inotersen side effects

14.9% of inotersen adverse event reports involve female patients and 23.5% involve male patients. The largest age group is elderly at 61%. These figures reflect who reports side effects, not underlying risk.

Sex

Female14.9%
Male23.5%
Unknown61.6%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6439.2%
65+60.8%

What is inotersen used for

Conditions and purposes for which patients were taking inotersen when the adverse event was reported.

Adenomatous Polyposis ColiAmyloidosisAmyloidosis SenileAcquired Attr AmyloidosisAdenomatous Polyposis ColiAmyloidosisAmyloidosis SenileCardiac AmyloidosisCardiac AmyloidosisCardiac Failure CongestiveFamilial AmyloidosisFamilial AmyloidosisFamilial HypertriglyceridaemiaHereditary Neuropathic AmyloidosisHereditary Neuropathic Amyloidosis

Showing 15 of 21 indications

Inotersen brand names and reporting trend

Inotersen is sold under the brand name Tegsedi.

Brand names

Tegsedi29

Quarterly reports (20162025)

2016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking inotersen with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.