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Inebilizumab Side Effects

The most commonly reported side effects of inebilizumab include neuromyelitis optica spectrum disorder, off label use, and headache, based on 481 FDA adverse event reports from 2019 to 2025.

Inebilizumab side effects

Percentages show how often each reaction appears relative to total reports for inebilizumab.

1
Neuromyelitis Optica Spectrum Disorder15.2%73
2
Off Label Use9.4%45
3
Headache7.3%35
4
Covid-195.8%28
5
Pneumonia5.4%26
6
Pain4.8%23
7
Nausea4.6%22
8
Urinary Tract Infection4.6%22
9
Fatigue4.2%20
10
Arthralgia4.0%19
11
Hypoaesthesia3.7%18
12
Product Storage Error2.9%14
13
Infusion Related Reaction2.7%13
14
Pyrexia2.7%13
15
Vomiting2.3%11

These are voluntary reports and do not establish that inebilizumab caused these reactions.

Report severity

58.8%Serious283 reports
29.7%Hospitalizations143 reports
6.7%Fatal32 reports

Seriousness is determined by the reporter, not by OpenClaim.

Inebilizumab drug interactions

Other drugs that appear in adverse event reports alongside inebilizumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Rituximab7.5%36
2
Prednisone3.5%17
3
Satralizumab2.5%12
4
Prednisolone2.1%10
5
Eculizumab2.1%10
6
Ravulizumab-cwvz1.9%9
7
Methotrexate1.5%7
8
Azathioprine1.5%7
9
Carbamazepine0.8%4
10
Tocilizumab0.8%4
11
Diphenhydramine0.6%3
12
Mycophenolate0.6%3
13
Methylprednisolone0.6%3
14
Ofatumumab0.6%3
15
Sacubitril0.4%2

Taken alongside

1
Acetaminophen4.8%23
2
Prednisolone4.6%22
3
Methylprednisolone4.4%21
4
Prednisone4.4%21
5
Diphenhydramine3.7%18
6
Gabapentin3.5%17
7
Baclofen3.5%17
8
Carbamazepine3.1%15
9
Magnesium-oxide2.9%14
10
Ergocalciferol2.7%13
11
Levothyroxine-sodium2.7%13
12
Pregabalin2.5%12
13
Duloxetine-hydrochloride2.5%12
14
Ravulizumab-cwvz2.3%11
15
Vonoprazan-fumarate2.1%10

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports inebilizumab side effects

54.9% of inebilizumab adverse event reports involve female patients and 9.8% involve male patients. The largest age group is adult at 78%. These figures reflect who reports side effects, not underlying risk.

Sex

Female54.9%
Male9.8%
Unknown35.3%

Age group

< 21.0%
2–110.3%
12–170.0%
18–6477.6%
65+21.0%

What is inebilizumab used for

Conditions and purposes for which patients were taking inebilizumab when the adverse event was reported.

Anti-aquaporin-4 Antibody PositiveAntisynthetase SyndromeAutoimmune DisorderChemotherapyExposure During PregnancyHeart Rate DecreasedHyperthyroidismImmunoglobulin G4 Related DiseaseImmunomodulatory TherapyMultiple SclerosisMyasthenia GravisNeuromyelitis Optica Spectrum DisorderNeuromyelitis Optica Spectrum DisorderNoninfective EncephalitisOff Label Use

Showing 15 of 20 indications

Inebilizumab brand names and reporting trend

Inebilizumab is sold under the brand name Uplizna.

Brand names

Uplizna201

Quarterly reports (20192025)

2019202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking inebilizumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.