OpenClaim

Indocyanine Side Effects

The most commonly reported side effects of indocyanine include urticaria, haemangioma congenital, and low birth weight baby, based on 154 FDA adverse event reports from 2004 to 2025. 4.5% of reports found the drug to be ineffective.

#1 Reported: UrticariaAll side effects ↓Top Co-Medication: Fluorescein-sodiumDrug interactions ↓58% of Reports Are AdultDemographics ↓

Indocyanine side effects

Percentages show how often each reaction appears relative to total reports for indocyanine.

1
Urticaria7.8%12
2
Haemangioma Congenital7.1%11
3
Low Birth Weight Baby7.1%11
4
Patent Ductus Arteriosus7.1%11
5
Visual Acuity Reduced6.5%10
6
Off Label Use5.8%9
7
Palpitations5.2%8
8
Dyspnoea5.2%8
9
Drug Ineffective4.5%7
10
Disease Progression4.5%7
11
Rash4.5%7
12
Liver Function Test Increased4.5%7
13
Anaphylactic Shock3.9%6
14
Tachycardia3.9%6
15
Pruritus3.9%6

These are voluntary reports and do not establish that indocyanine caused these reactions.

Report severity

86.4%Serious133 reports
23.4%Hospitalizations36 reports
1.9%Fatal3 reports

Seriousness is determined by the reporter, not by OpenClaim.

Indocyanine drug interactions

Other drugs that appear in adverse event reports alongside indocyanine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Fluorescein-sodium22.1%34
2
Verteporfin9.1%14
3
Ranibizumab7.8%12
4
Propofol7.8%12
5
Amlodipine7.1%11
6
Labetalol-hydrochloride7.1%11
7
Metformin7.1%11
8
Aflibercept5.2%8
9
Metronidazole5.2%8
10
Fentanyl4.5%7
11
Rocuronium-bromide4.5%7
12
Acetaminophen3.9%6
13
Remifentanil-hydrochloride3.9%6
14
Dexamethasone3.9%6
15
Cefuroxime3.9%6

Taken alongside

1
Rocuronium-bromide8.4%13
2
Fluorescein-sodium7.8%12
3
Propofol7.8%12
4
Insulin7.1%11
5
Fentanyl5.8%9
6
Vancomycin5.8%9
7
Ondansetron5.8%9
8
Acetaminophen5.2%8
9
Lidocaine5.2%8
10
Esomeprazole5.2%8
11
Glycopyrrolate5.2%8
12
Aflibercept4.5%7
13
Pseudoephedrine3.9%6
14
Sodium-chloride3.9%6
15
Amlodipine3.9%6

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports indocyanine side effects

54.5% of indocyanine adverse event reports involve female patients and 31.8% involve male patients. The largest age group is adult at 58%. These figures reflect who reports side effects, not underlying risk.

Sex

Female54.5%
Male31.8%
Unknown13.6%

Age group

< 28.4%
2–112.5%
12–171.7%
18–6458.0%
65+29.4%

What is indocyanine used for

Conditions and purposes for which patients were taking indocyanine when the adverse event was reported.

AngiogramAngiogram CerebralAngiogram RetinaAngiogram RetinaBreast ReconstructionBowel PreparationCardiac Imaging ProcedureChorioretinopathyChoroidal NeovascularisationChoroiditisCoronary Artery BypassCentral Serous ChorioretinopathyConstipationDiabetes MellitusDiagnostic Procedure

Showing 15 of 43 indications

Indocyanine brand names and reporting trend

Indocyanine is sold under the brand name Ic-green.

Brand names

Ic-green146

Quarterly reports (2004–2025)

200420202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking indocyanine with another medication?

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