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Imlunestrant Side Effects

The most commonly reported side effects of imlunestrant include fatigue, influenza like illness, and insomnia, based on 19 FDA adverse event reports from 2005 to 2025.

Imlunestrant side effects

Percentages show how often each reaction appears relative to total reports for imlunestrant.

1
Fatigue10.5%2
2
Influenza Like Illness10.5%2
3
Insomnia10.5%2
4
Nausea10.5%2
5
Atrial Fibrillation10.5%2
6
Back Pain10.5%2
7
Hyponatraemia10.5%2
8
Abdominal Distension5.3%1
9
Anorexia5.3%1
10
Blood Glucose Increased5.3%1
11
Chills5.3%1
12
Injection Site Bruising5.3%1
13
Injection Site Pain5.3%1
14
Malaise5.3%1
15
Weight Decreased5.3%1

These are voluntary reports and do not establish that imlunestrant caused these reactions.

Report severity

57.9%Serious11 reports
31.6%Hospitalizations6 reports
0.0%Fatal0 reports

Seriousness is determined by the reporter, not by OpenClaim.

Imlunestrant drug interactions

Other drugs that appear in adverse event reports alongside imlunestrant. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Abemaciclib26.3%5
2
Quetiapine-fumarate10.5%2
3
Anastrozole10.5%2
4
Trastuzumab10.5%2
5
Pramlintide-acetate5.3%1
6
Adalimumab5.3%1
7
Gadopentetate-dimeglumine5.3%1
8
Darunavir5.3%1
9
Etravirine5.3%1
10
Ritonavir5.3%1
11
Telaprevir5.3%1
12
Certolizumab-pegol5.3%1
13
Cladribine5.3%1
14
Everolimus5.3%1
15
Exemestane5.3%1

Taken alongside

1
Acetaminophen21.1%4
2
Clonazepam21.1%4
3
Hydrocodone15.8%3
4
Alprazolam15.8%3
5
Loperamide-hydrochloride15.8%3
6
Insulin10.5%2
7
Ergocalciferol10.5%2
8
Lisinopril10.5%2
9
Acyclovir10.5%2
10
Allopurinol10.5%2
11
Furosemide10.5%2
12
Albuterol10.5%2
13
Ipratropium-bromide10.5%2
14
Potassium-chloride10.5%2
15
Trazodone-hydrochloride10.5%2

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports imlunestrant side effects

68.4% of imlunestrant adverse event reports involve female patients and 31.6% involve male patients. The largest age group is adult at 85%. These figures reflect who reports side effects, not underlying risk.

Sex

Female68.4%
Male31.6%
Unknown0.0%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6484.6%
65+15.4%

What is imlunestrant used for

Conditions and purposes for which patients were taking imlunestrant when the adverse event was reported.

Breast CancerInsomniaInvasive Lobular Breast CarcinomaProduct Used For Unknown IndicationSleep Disorder

Imlunestrant brand names and reporting trend

Imlunestrant is sold under the brand name Inluriyo.

Brand names

Inluriyo18

Quarterly reports (20052025)

20052025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking imlunestrant with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.