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Imiglucerase Side Effects

The most commonly reported side effects of imiglucerase include exposure during pregnancy, pyrexia, and fatigue, based on 4,586 FDA adverse event reports from 2004 to 2025.

Imiglucerase side effects

Percentages show how often each reaction appears relative to total reports for imiglucerase.

1
Exposure During Pregnancy3.6%164
2
Pyrexia3.5%159
3
Fatigue3.1%142
4
Weight Increased2.8%127
5
Death2.6%119
6
Malaise2.6%118
7
Weight Decreased2.3%105
8
Dizziness2.2%101
9
Dyspnoea2.1%95
10
Pneumonia2.0%94
11
Arthralgia2.0%93
12
Pain2.0%92
13
Fall2.0%92
14
Bone Pain1.9%89
15
Parkinson^s Disease1.8%84

These are voluntary reports and do not establish that imiglucerase caused these reactions.

Report severity

70.6%Serious3,238 reports
31.3%Hospitalizations1,434 reports
17.7%Fatal811 reports

Seriousness is determined by the reporter, not by OpenClaim.

Imiglucerase drug interactions

Other drugs that appear in adverse event reports alongside imiglucerase. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Velaglucerase-alfa1.2%56
2
Eliglustat-tartrate1.1%52
3
Rivastigmine1.1%52
4
Quetiapine-fumarate1.1%49
5
Lansoprazole1.1%49
6
Citalopram-hydrobromide1.1%49
7
Bisoprolol-fumarate1.1%49
8
Cyclizine-lactate1.0%48
9
Ropinirole-hydrochloride1.0%48
10
Lactulose1.0%48
11
Miglustat0.7%31
12
Taliglucerase-alfa0.2%8
13
Certolizumab-pegol0.1%6
14
Zoledronic-acid0.1%5
15
Etanercept0.1%5

Taken alongside

1
Epinephrine10.6%488
2
Sodium-chloride9.7%445
3
Sterile8.4%387
4
Diphenhydramine8.2%375
5
Acetaminophen5.4%248
6
Ammonium4.7%214
7
Ergocalciferol3.6%164
8
Heparin3.0%139
9
Lidocaine2.6%119
10
Ibuprofen2.2%103
11
Calcium2.0%94
12
Cetirizine-hydrochloride1.7%77
13
Hydrocortisone1.6%72
14
Levothyroxine-sodium1.5%69
15
Methylprednisolone1.5%67

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports imiglucerase side effects

52.2% of imiglucerase adverse event reports involve female patients and 35.5% involve male patients. The largest age group is adult at 55%. These figures reflect who reports side effects, not underlying risk.

Sex

Female52.2%
Male35.5%
Unknown12.2%

Age group

< 25.0%
2–1115.7%
12–177.8%
18–6455.3%
65+16.1%

What is imiglucerase used for

Conditions and purposes for which patients were taking imiglucerase when the adverse event was reported.

AmyloidosisComplement Factor AbnormalCystitis NoninfectiveCombined ImmunodeficiencyComplement Factor AbnormalDrug Exposure Before PregnancyDrug Exposure During PregnancyDrug Exposure Via Breast MilkExposure During Breast FeedingEnzyme Activity AbnormalFabry^s DiseaseFoetal Exposure During PregnancyFoetal Exposure Timing UnspecifiedFabry^s DiseaseGaucher's Disease

Showing 15 of 53 indications

Imiglucerase brand names and reporting trend

Imiglucerase is sold under the brand name Cerezyme.

Brand names

Cerezyme345

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking imiglucerase with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.