OpenClaim

Imetelstat Side Effects

The most commonly reported side effects of imetelstat include thrombocytopenia, neutropenia, and platelet count decreased, based on 176 FDA adverse event reports from 2013 to 2025.

Imetelstat side effects

Percentages show how often each reaction appears relative to total reports for imetelstat.

1
Thrombocytopenia18.8%33
2
Neutropenia14.8%26
3
Platelet Count Decreased13.6%24
4
Haemoglobin Decreased11.9%21
5
Cytopenia11.4%20
6
Anaemia8.0%14
7
Infection6.8%12
8
Hypokalaemia6.3%11
9
Nausea6.3%11
10
Acute Myeloid Leukaemia6.3%11
11
Diarrhoea6.3%11
12
Pneumonia6.3%11
13
Vomiting5.7%10
14
Constipation5.7%10
15
Asthenia5.7%10

These are voluntary reports and do not establish that imetelstat caused these reactions.

Report severity

63.6%Serious112 reports
26.1%Hospitalizations46 reports
11.4%Fatal20 reports

Seriousness is determined by the reporter, not by OpenClaim.

Imetelstat drug interactions

Other drugs that appear in adverse event reports alongside imetelstat. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Levofloxacin5.7%10
2
Acetaminophen5.7%10
3
Posaconazole5.1%9
4
Simvastatin4.0%7
5
Rivaroxaban1.7%3
6
Ruxolitinib1.1%2
7
Cisplatin1.1%2
8
Denosumab1.1%2
9
Hydroxyurea1.1%2
10
Hydrochlorothiazide1.1%2
11
Deferasirox1.1%2
12
Thalidomide0.6%1
13
Bevacizumab0.6%1
14
Gemcitabine0.6%1
15
Letrozole0.6%1

Taken alongside

1
Acyclovir7.4%13
2
Omeprazole6.3%11
3
Amiloride-hydrochloride5.1%9
4
Hydrochlorothiazide5.1%9
5
Mesalamine5.1%9
6
Tramadol-hydrochloride5.1%9
7
Hydroxyurea5.1%9
8
Meropenem4.5%8
9
Sodium-chloride4.5%8
10
Technetium-tc-99m-sodium-pertechnetate-generator4.5%8
11
Oxygen4.5%8
12
Potassium-chloride4.5%8
13
Atorvastatin-calcium2.8%5
14
Amlodipine2.8%5
15
Dexamethasone2.3%4

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports imetelstat side effects

26.7% of imetelstat adverse event reports involve female patients and 44.9% involve male patients. The largest age group is elderly at 77%. These figures reflect who reports side effects, not underlying risk.

Sex

Female26.7%
Male44.9%
Unknown28.4%

Age group

< 20.0%
2–110.0%
12–170.8%
18–6422.2%
65+77.0%

What is imetelstat used for

Conditions and purposes for which patients were taking imetelstat when the adverse event was reported.

ChemotherapyHepatic Cancer MetastaticMyelodysplastic SyndromeMyelodysplastic Syndrome/myeloproliferative Neoplasm Overlap SyndromeMyelofibrosisNon-small Cell Lung CancerProduct Used For Unknown IndicationProduct Used For Unknown IndicationSf3b1 Gene Mutation

Imetelstat brand names and reporting trend

Imetelstat is sold under the brand name Rytelo.

Brand names

Rytelo38

Quarterly reports (20132025)

201320162025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking imetelstat with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.