OpenClaim

Iloperidone Side Effects

The most commonly reported side effects of iloperidone include insomnia, fatigue, and anxiety, based on 1,410 FDA adverse event reports from 2010 to 2025. 6.1% of reports found the drug to be ineffective.

Iloperidone side effects

Percentages show how often each reaction appears relative to total reports for iloperidone.

1
Drug Ineffective6.1%86
2
Insomnia4.3%61
3
Fatigue3.9%55
4
Anxiety3.9%55
5
Dizziness3.7%52
6
Dizziness3.4%48
7
Suicidal Ideation3.2%45
8
Dyskinesia3.0%43
9
Off Label Use3.0%43
10
Weight Increased2.9%41
11
Aggression2.9%41
12
Speech Disorder2.8%40
13
Weight Increased2.4%34
14
Sleep Disorder2.4%34
15
Crying2.4%34

These are voluntary reports and do not establish that iloperidone caused these reactions.

Report severity

51.4%Serious725 reports
16.0%Hospitalizations225 reports
4.2%Fatal59 reports

Seriousness is determined by the reporter, not by OpenClaim.

Iloperidone drug interactions

Other drugs that appear in adverse event reports alongside iloperidone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Aripiprazole6.3%89
2
Quetiapine-fumarate4.5%64
3
Ziprasidone4.0%57
4
Risperidone3.8%53
5
Olanzapine3.3%46
6
Lithium2.8%40
7
Carbamazepine2.8%39
8
Clonidine2.6%37
9
Methylphenidate2.6%36
10
Chlorpromazine2.4%34
11
Clozapine2.3%33
12
Atomoxetine-hydrochloride2.3%32
13
Lisdexamfetamine-dimesylate2.2%31
14
Paliperidone2.1%30
15
Valproic-acid2.1%30

Taken alongside

1
Clonazepam5.3%75
2
Lamotrigine4.0%56
3
Quetiapine-fumarate3.9%55
4
Gabapentin3.7%52
5
Levothyroxine-sodium3.6%51
6
Divalproex-sodium3.5%49
7
Benztropine-mesylate3.4%48
8
Lithium3.2%45
9
Olanzapine3.1%44
10
Lorazepam3.0%42
11
Zolpidem-tartrate2.9%41
12
Acetaminophen2.8%40
13
Metformin2.8%40
14
Aripiprazole2.8%39
15
Albuterol2.6%37

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports iloperidone side effects

44.9% of iloperidone adverse event reports involve female patients and 42.9% involve male patients. The largest age group is adult at 82%. These figures reflect who reports side effects, not underlying risk.

Sex

Female44.9%
Male42.9%
Unknown12.2%

Age group

< 20.0%
2–115.9%
12–174.4%
18–6482.2%
65+7.5%

What is iloperidone used for

Conditions and purposes for which patients were taking iloperidone when the adverse event was reported.

Abnormal BehaviourAccidental Exposure To Product By ChildAffective DisorderAggressionAgitationAntidepressant TherapyAnxietyAsperger^s DisorderAttention Deficit/hyperactivity DisorderAutismAffective DisorderAnxietyAutism Spectrum DisorderBipolar DisorderBipolar I Disorder

Showing 15 of 65 indications

Iloperidone brand names and reporting trend

Iloperidone is sold under the brand name Iloperidone.

Brand names

Iloperidone153

Quarterly reports (20102025)

201020122016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking iloperidone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.