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Ifosfamide Side Effects

The most commonly reported side effects of ifosfamide include off label use, febrile neutropenia, and disease progression, based on 21,766 FDA adverse event reports from 2004 to 2025. 7.0% of reports found the drug to be ineffective.

Ifosfamide side effects

Percentages show how often each reaction appears relative to total reports for ifosfamide.

1
Off Label Use12.5%2,711
2
Febrile Neutropenia11.7%2,548
3
Disease Progression9.6%2,088
4
Neutropenia7.7%1,679
5
Drug Ineffective7.0%1,519
6
Thrombocytopenia6.3%1,381
7
Anaemia5.4%1,169
8
Product Use In Unapproved Indication4.4%964
9
Pyrexia4.0%877
10
Sepsis3.7%804
11
Infection3.2%707
12
Pancytopenia3.2%706
13
Malignant Neoplasm Progression3.2%702
14
Vomiting3.1%670
15
Nausea3.0%662

These are voluntary reports and do not establish that ifosfamide caused these reactions.

Report severity

97.5%Serious21,220 reports
31.0%Hospitalizations6,740 reports
20.5%Fatal4,453 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ifosfamide drug interactions

Other drugs that appear in adverse event reports alongside ifosfamide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Etoposide61.9%13,463
2
Doxorubicin-hydrochloride43.8%9,526
3
Vincristine-sulfate35.7%7,767
4
Carboplatin33.2%7,217
5
Cyclophosphamide33.0%7,186
6
Rituximab28.2%6,128
7
Methotrexate22.3%4,858
8
Cisplatin20.7%4,513
9
Cytarabine18.9%4,120
10
Dexamethasone18.0%3,910
11
Prednisone13.0%2,840
12
Mesna10.0%2,167
13
Gemcitabine9.9%2,163
14
Prednisolone7.1%1,544
15
Paclitaxel5.8%1,254

Taken alongside

1
Etoposide8.8%1,918
2
Dexamethasone6.3%1,370
3
Doxorubicin-hydrochloride6.0%1,309
4
Mesna5.6%1,214
5
Vincristine-sulfate5.1%1,101
6
Cyclophosphamide4.9%1,076
7
Ondansetron4.6%1,009
8
Carboplatin4.4%964
9
Acetaminophen3.6%788
10
Cisplatin3.1%673
11
Methotrexate3.1%668
12
Filgrastim2.9%626
13
Cytarabine2.8%618
14
Acyclovir2.7%596
15
Sulfamethoxazole2.6%570

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ifosfamide side effects

33.0% of ifosfamide adverse event reports involve female patients and 45.3% involve male patients. The largest age group is adult at 58%. These figures reflect who reports side effects, not underlying risk.

Sex

Female33.0%
Male45.3%
Unknown21.7%

Age group

< 22.7%
2–1113.2%
12–1712.8%
18–6458.0%
65+13.3%

What is ifosfamide used for

Conditions and purposes for which patients were taking ifosfamide when the adverse event was reported.

Abdominal NeoplasmAbdominal Wall NeoplasmAcute LeukaemiaAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Myeloid LeukaemiaAdenocarcinomaAdenocarcinoma Of The CervixAdjuvant TherapyAdrenal Gland CancerAdrenocortical CarcinomaAdult T-cell Lymphoma/leukaemiaAdult T-cell Lymphoma/leukaemia RefractoryAdult T-cell Lymphoma/leukaemia Stage IvAdverse Drug Reaction

Showing 15 of 1,179 indications

Ifosfamide brand names and reporting trend

Ifosfamide is sold under the brand name Ifex.

Brand names

Ifex26,067

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ifosfamide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.