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Icodextrin Side Effects

The most commonly reported side effects of icodextrin include death, peritonitis, and peritoneal dialysis complication, based on 31,665 FDA adverse event reports from 2004 to 2025.

Icodextrin side effects

Percentages show how often each reaction appears relative to total reports for icodextrin.

1
Death16.1%5,083
2
Peritonitis5.3%1,663
3
Peritoneal Dialysis Complication4.2%1,345
4
Peritonitis Bacterial3.9%1,231
5
Death3.8%1,200
6
Hypotension3.4%1,066
7
Pneumonia2.6%834
8
Myocardial Infarction2.5%800
9
Infection2.2%707
10
Fluid Overload2.2%683
11
Fall2.0%628
12
Dehydration1.9%597
13
Asthenia1.8%563
14
Drug Hypersensitivity1.7%551
15
Sepsis1.7%544

These are voluntary reports and do not establish that icodextrin caused these reactions.

Report severity

84.1%Serious26,633 reports
46.7%Hospitalizations14,799 reports
33.4%Fatal10,588 reports

Seriousness is determined by the reporter, not by OpenClaim.

Icodextrin drug interactions

Other drugs that appear in adverse event reports alongside icodextrin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dextrose57.2%18,111
2
Sodium-chloride18.0%5,712
3
Magnesium-chloride18.0%5,707
4
Calcium-chloride17.2%5,435
5
Sodium-lactate17.1%5,430
6
Calcium11.4%3,608
7
Hexachlorophene1.3%413
8
Potassium-chloride0.9%291
9
Sodium-acetate0.9%285
10
Sodium-gluconate0.9%279
11
Insulin0.2%60
12
Furosemide0.2%59
13
Vancomycin0.1%43
14
Heparin0.1%42
15
Nifedipine0.1%39

Taken alongside

1
Insulin1.5%477
2
Furosemide1.0%324
3
Aspirin0.9%283
4
Amlodipine0.8%243
5
Sevelamer0.7%218
6
Atorvastatin-calcium0.6%192
7
Calcitriol0.6%189
8
Omeprazole0.5%165
9
Estropipate0.5%163
10
Metoprolol0.5%163
11
Sodium-chloride0.5%160
12
Magnesium-chloride0.5%147
13
Darbepoetin-alfa0.5%147
14
Ergocalciferol0.4%142
15
Dextrose0.4%137

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports icodextrin side effects

38.2% of icodextrin adverse event reports involve female patients and 56.5% involve male patients. The largest age group is adult at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female38.2%
Male56.5%
Unknown5.3%

Age group

< 20.1%
2–110.4%
12–170.4%
18–6452.6%
65+46.5%

What is icodextrin used for

Conditions and purposes for which patients were taking icodextrin when the adverse event was reported.

Abdominal Cavity DrainageAdhesionAdverse EventAmyloidosisAnalgesic TherapyAnuriaArteriosclerosisAscitesAutomated Peritoneal DialysisAzotaemiaAttention Deficit Hyperactivity DisorderAzotaemiaBlood Creatine IncreasedBlood Creatinine IncreasedBlood Glucose Abnormal

Showing 15 of 165 indications

Icodextrin brand names and reporting trend

Icodextrin is sold under the brand name Extraneal.

Brand names

Extraneal906

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking icodextrin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.