The most commonly reported side effects of ibuprofen include pain, fatigue, and nausea, based on 345,963 FDA adverse event reports from 2004 to 2025. 8.2% of reports found the drug to be ineffective.
Percentages show how often each reaction appears relative to total reports for ibuprofen.
These are voluntary reports and do not establish that ibuprofen caused these reactions.
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Seriousness is determined by the reporter, not by OpenClaim.
Other drugs that appear in adverse event reports alongside ibuprofen. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.
Also suspected
Taken alongside
Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.
57.2% of ibuprofen adverse event reports involve female patients and 30.2% involve male patients. The largest age group is adult at 66%. These figures reflect who reports side effects, not underlying risk.
Sex
Age group
Conditions and purposes for which patients were taking ibuprofen when the adverse event was reported.
Showing 15 of 2,779 indications
Ibuprofen is sold under brand names including Reprexain, Ibuprofen Sodium, Neoprofen.
An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.
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