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Ibandronate Side Effects

The most commonly reported side effects of ibandronate include femur fracture, arthralgia, and arthralgia, based on 25,662 FDA adverse event reports from 2004 to 2025.

Ibandronate side effects

Percentages show how often each reaction appears relative to total reports for ibandronate.

1
Femur Fracture5.3%1,369
2
Arthralgia4.8%1,225
3
Arthralgia4.5%1,152
4
Pain3.9%992
5
Pain In Extremity3.6%919
6
Pain In Extremity3.6%913
7
Nausea3.3%857
8
Back Pain3.2%831
9
Diarrhoea3.2%812
10
Fall3.1%803
11
Diarrhoea3.1%797
12
Nausea3.0%763
13
Myalgia2.9%732
14
Pain2.8%720
15
Back Pain2.8%708

These are voluntary reports and do not establish that ibandronate caused these reactions.

Report severity

62.5%Serious16,027 reports
19.2%Hospitalizations4,923 reports
4.7%Fatal1,208 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ibandronate drug interactions

Other drugs that appear in adverse event reports alongside ibandronate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Alendronate-sodium9.2%2,370
2
Adalimumab2.8%725
3
Risedronate-sodium2.7%690
4
Zoledronic-acid1.6%419
5
Etanercept1.4%369
6
Cholecalciferol1.1%272
7
Teriparatide0.9%231
8
Lenalidomide0.8%213
9
Letrozole0.8%205
10
Anastrozole0.8%202
11
Dalfampridine0.8%201
12
Pregabalin0.8%199
13
Omeprazole0.8%196
14
Denosumab0.8%195
15
Esomeprazole0.7%190

Taken alongside

1
Calcium8.8%2,267
2
Levothyroxine-sodium8.6%2,214
3
Ergocalciferol8.3%2,136
4
Aspirin7.0%1,807
5
Acetaminophen5.9%1,523
6
Omeprazole5.2%1,322
7
Prednisone4.8%1,223
8
Atorvastatin-calcium4.6%1,175
9
Metoprolol3.7%953
10
Simvastatin3.7%945
11
Amlodipine3.7%941
12
Furosemide3.6%918
13
Hydrochlorothiazide3.5%909
14
Fluticasone3.5%895
15
Albuterol3.5%888

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ibandronate side effects

88.7% of ibandronate adverse event reports involve female patients and 5.5% involve male patients. The largest age group is elderly at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female88.7%
Male5.5%
Unknown5.8%

Age group

< 2<0.1%
2–11<0.1%
12–17<0.1%
18–6442.7%
65+57.2%

What is ibandronate used for

Conditions and purposes for which patients were taking ibandronate when the adverse event was reported.

Abdominal DiscomfortAdverse Drug ReactionAnkle FractureAnticoagulant TherapyAntisynthetase SyndromeArthralgiaArthritisArthropathyAstheniaAutoimmune DisorderAbdominal DiscomfortAcneAntisynthetase SyndromeArthralgiaArthritis

Showing 15 of 230 indications

Ibandronate brand names and reporting trend

Ibandronate is sold under the brand name Boniva.

Brand names

Boniva4,571

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ibandronate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.