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Hydroxypropyl Side Effects

The most commonly reported side effects of hydroxypropyl include product availability issue, therapy interrupted, and dry eye, based on 371 FDA adverse event reports from 2004 to 2025. 6.5% of reports found the drug to be ineffective.

Hydroxypropyl side effects

Percentages show how often each reaction appears relative to total reports for hydroxypropyl.

1
Product Availability Issue29.6%110
2
Therapy Interrupted27.8%103
3
Dry Eye18.3%68
4
Eye Pain16.4%61
5
Eye Irritation14.6%54
6
Vision Blurred12.7%47
7
Intentional Product Use Issue10.2%38
8
Wrong Technique In Product Usage Process8.4%31
9
Product Supply Issue8.4%31
10
Ocular Hyperaemia7.3%27
11
Drug Ineffective6.5%24
12
Visual Impairment6.5%24
13
Eye Disorder6.2%23
14
Ocular Discomfort5.9%22
15
Foreign Body Sensation In Eyes4.3%16

These are voluntary reports and do not establish that hydroxypropyl caused these reactions.

Report severity

23.2%Serious86 reports
6.2%Hospitalizations23 reports
0.5%Fatal2 reports

Seriousness is determined by the reporter, not by OpenClaim.

Hydroxypropyl drug interactions

Other drugs that appear in adverse event reports alongside hydroxypropyl. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sodium-oxybate2.7%10
2
Lifitegrast2.2%8
3
Lenalidomide1.6%6
4
Cenegermin-bkbj1.3%5
5
Adalimumab1.1%4
6
Cyclosporine1.1%4
7
Dexamethasone0.5%2
8
Latanoprost0.5%2
9
Orlistat0.5%2
10
Titanium-dioxide0.5%2
11
Pioglitazone-hydrochloride0.5%2
12
Denosumab0.5%2
13
Interferon0.5%2
14
Bupropion0.5%2
15
Etanercept0.5%2

Taken alongside

1
Cyclosporine14.0%52
2
Ergocalciferol10.0%37
3
Levothyroxine-sodium9.4%35
4
Aspirin6.7%25
5
Acetaminophen5.7%21
6
Hydroxychloroquine-sulfate5.4%20
7
Prednisone5.1%19
8
Gabapentin5.1%19
9
Omeprazole4.6%17
10
Buspirone-hydrochloride4.3%16
11
Atorvastatin-calcium4.0%15
12
Calcium3.8%14
13
Duloxetine-hydrochloride3.5%13
14
Fish3.5%13
15
Estradiol3.2%12

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports hydroxypropyl side effects

86.5% of hydroxypropyl adverse event reports involve female patients and 10.2% involve male patients. The largest age group is elderly at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female86.5%
Male10.2%
Unknown3.2%

Age group

< 20.0%
2–111.0%
12–170.0%
18–6442.4%
65+56.5%

What is hydroxypropyl used for

Conditions and purposes for which patients were taking hydroxypropyl when the adverse event was reported.

Autoimmune DisorderBlepharitisCorneal AbrasionDry EyeDry EyeEye DisorderEye InflammationEye UlcerEyelid DisorderEye DisorderEye PainEye UlcerForeign Body In EyeGlareGranulomatosis With Polyangiitis

Showing 15 of 33 indications

Hydroxypropyl brand names and reporting trend

Hydroxypropyl is sold under the brand name Lacrisert.

Brand names

Lacrisert10

Quarterly reports (20042025)

2004201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking hydroxypropyl with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.