OpenClaim

Hydrogen Side Effects

The most commonly reported side effects of hydrogen include application site discolouration, application site erythema, and product complaint, based on 735 FDA adverse event reports from 2004 to 2025. 13.1% of reports found the drug to be ineffective.

Hydrogen side effects

Percentages show how often each reaction appears relative to total reports for hydrogen.

1
Drug Ineffective13.1%96
2
Application Site Discolouration6.9%51
3
Application Site Erythema5.2%38
4
Product Complaint4.9%36
5
Nausea4.5%33
6
Fatigue4.5%33
7
Application Site Pain3.7%27
8
Rash3.1%23
9
Headache3.1%23
10
Erythema2.9%21
11
Vomiting2.9%21
12
Pruritus2.7%20
13
Pain2.7%20
14
Impaired Healing2.4%18
15
Dyspnoea2.4%18

These are voluntary reports and do not establish that hydrogen caused these reactions.

Report severity

55.8%Serious410 reports
24.6%Hospitalizations181 reports
8.2%Fatal60 reports

Seriousness is determined by the reporter, not by OpenClaim.

Hydrogen drug interactions

Other drugs that appear in adverse event reports alongside hydrogen. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ibuprofen3.4%25
2
Adalimumab2.7%20
3
Lithium2.6%19
4
Dexamethasone2.4%18
5
Olanzapine2.2%16
6
Aspirin2.2%16
7
Acetaminophen2.0%15
8
Metformin1.8%13
9
Ivermectin1.8%13
10
Sodium-chloride1.6%12
11
Verapamil-hydrochloride1.6%12
12
Glipizide1.6%12
13
Lovastatin1.6%12
14
Lenalidomide1.5%11
15
Hydrocortisone1.4%10

Taken alongside

1
Acetaminophen9.7%71
2
Aspirin6.4%47
3
Ergocalciferol6.1%45
4
Albuterol5.7%42
5
Omeprazole5.6%41
6
Ibuprofen5.4%40
7
Furosemide5.3%39
8
Levothyroxine-sodium4.9%36
9
Ondansetron4.8%35
10
Dexamethasone4.6%34
11
Atorvastatin-calcium4.4%32
12
Hydrocortisone4.1%30
13
Calcium3.9%29
14
Gabapentin3.9%29
15
Oxycodone3.9%29

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports hydrogen side effects

55.1% of hydrogen adverse event reports involve female patients and 33.9% involve male patients. The largest age group is adult at 66%. These figures reflect who reports side effects, not underlying risk.

Sex

Female55.1%
Male33.9%
Unknown11.0%

Age group

< 20.6%
2–111.8%
12–173.2%
18–6465.6%
65+28.8%

What is hydrogen used for

Conditions and purposes for which patients were taking hydrogen when the adverse event was reported.

AccidentAccidental ExposureAccidental Exposure To ProductAbscessAbscess DrainageAmyotrophic Lateral SclerosisAnal AbscessArthropod BiteArthropod StingBlisterBone DisorderBreath OdourCandidiasisCerumen ImpactionCerumen Removal

Showing 15 of 125 indications

Hydrogen brand names and reporting trend

Hydrogen is sold under the brand name Eskata.

Brand names

Eskata546

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking hydrogen with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.