The most commonly reported side effects of hydrochlorothiazide include fatigue, nausea, and diarrhoea, based on 279,493 FDA adverse event reports from 2004 to 2025. 4.7% of reports found the drug to be ineffective.
Percentages show how often each reaction appears relative to total reports for hydrochlorothiazide.
These are voluntary reports and do not establish that hydrochlorothiazide caused these reactions.
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Other drugs that appear in adverse event reports alongside hydrochlorothiazide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.
Also suspected
Taken alongside
Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.
58.0% of hydrochlorothiazide adverse event reports involve female patients and 34.9% involve male patients. The largest age group is elderly at 54%. These figures reflect who reports side effects, not underlying risk.
Sex
Age group
Conditions and purposes for which patients were taking hydrochlorothiazide when the adverse event was reported.
Showing 15 of 1,304 indications
Hydrochlorothiazide is sold under the brand name Hydralazine Hydrochloride W/ Hydrochlorothiazide 50/50.
An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.
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