OpenClaim

Hetacillin Side Effects

The most commonly reported side effects of hetacillin include pain, vomiting, and osteomyelitis, based on 13 FDA adverse event reports from 2013 to 2025.

Hetacillin side effects

Percentages show how often each reaction appears relative to total reports for hetacillin.

1
Pain15.4%2
2
Vomiting15.4%2
3
Osteomyelitis15.4%2
4
Injection Site Swelling15.4%2
5
Off Label Use15.4%2
6
Poor Dental Condition7.7%1
7
Injury7.7%1
8
Anxiety7.7%1
9
Bone Pain7.7%1
10
Actinomycosis7.7%1
11
Bone Disorder7.7%1
12
Decreased Interest7.7%1
13
Headache7.7%1
14
Candida Infection7.7%1
15
Chronic Obstructive Pulmonary Disease7.7%1

These are voluntary reports and do not establish that hetacillin caused these reactions.

Report severity

76.9%Serious10 reports
46.2%Hospitalizations6 reports
0.0%Fatal0 reports

Seriousness is determined by the reporter, not by OpenClaim.

Hetacillin drug interactions

Other drugs that appear in adverse event reports alongside hetacillin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Natalizumab23.1%3
2
Incobotulinumtoxina15.4%2
3
Zoledronic-acid7.7%1
4
Pamidronate-disodium7.7%1
5
Dalfampridine7.7%1
6
Rituximab7.7%1
7
Adalimumab7.7%1
8
Prednisone7.7%1
9
Aspirin7.7%1
10
Abatacept7.7%1
11
Onabotulinumtoxina7.7%1
12
Secukinumab7.7%1

Taken alongside

1
Acetaminophen30.8%4
2
Methotrexate30.8%4
3
Clonazepam30.8%4
4
Ergocalciferol23.1%3
5
Hydrochlorothiazide15.4%2
6
Gabapentin15.4%2
7
Baclofen15.4%2
8
Prednisone15.4%2
9
Ibuprofen15.4%2
10
Omeprazole15.4%2
11
Calcium15.4%2
12
Folic-acid15.4%2
13
Amitriptyline-hydrochloride15.4%2
14
Triamterene7.7%1
15
Cyclobenzaprine-hydrochloride7.7%1

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports hetacillin side effects

92.3% of hetacillin adverse event reports involve female patients and 7.7% involve male patients. The largest age group is adult at 86%. These figures reflect who reports side effects, not underlying risk.

Sex

Female92.3%
Male7.7%
Unknown0.0%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6485.7%
65+14.3%

What is hetacillin used for

Conditions and purposes for which patients were taking hetacillin when the adverse event was reported.

Dermal Filler InjectionProduct Used For Unknown IndicationProduct Used For Unknown IndicationSkin Cosmetic ProcedureThrombosis Prophylaxis

Hetacillin brand names and reporting trend

Hetacillin is sold under the brand name Versapen.

Brand names

Versapen1

Quarterly reports (20132025)

20132025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking hetacillin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.