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Halofantrine Side Effects

The most commonly reported side effects of halofantrine include malaise, loss of consciousness, and circulatory collapse, based on 27 FDA adverse event reports from 2004 to 2024.

Halofantrine side effects

Percentages show how often each reaction appears relative to total reports for halofantrine.

1
Malaise22.2%6
2
Loss Of Consciousness14.8%4
3
Circulatory Collapse11.1%3
4
Chromaturia11.1%3
5
Anaemia Macrocytic11.1%3
6
Cardiac Arrest11.1%3
7
Cardiac Failure11.1%3
8
Thrombocytopenia11.1%3
9
Torsade De Pointes11.1%3
10
Ventricular Tachycardia11.1%3
11
Sudden Death7.4%2
12
Pyrexia7.4%2
13
Arrhythmia7.4%2
14
Death7.4%2
15
Syncope7.4%2

These are voluntary reports and do not establish that halofantrine caused these reactions.

Report severity

92.6%Serious25 reports
37.0%Hospitalizations10 reports
33.3%Fatal9 reports

Seriousness is determined by the reporter, not by OpenClaim.

Halofantrine drug interactions

Other drugs that appear in adverse event reports alongside halofantrine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Hydroxychloroquine-sulfate7.4%2
2
Acetaminophen3.7%1
3
Mefloquine-hydrochloride3.7%1
4
Rivastigmine3.7%1
5
Ruxolitinib3.7%1
6
Gabapentin3.7%1
7
Metoprolol3.7%1
8
Sodium-zirconium-cyclosilicate3.7%1
9
Atovaquone3.7%1
10
Proguanil-hydrochloride3.7%1
11
Palbociclib3.7%1

Taken alongside

1
Acetaminophen25.9%7
2
Acebutolol-hydrochloride11.1%3
3
Proguanil-hydrochloride7.4%2
4
Aspirin7.4%2
5
Levothyroxine-sodium7.4%2
6
Chloroquine3.7%1
7
Ceftriaxone-sodium3.7%1
8
Levofloxacin3.7%1
9
Ramipril3.7%1
10
Diazepam3.7%1
11
Anagrelide-hydrochloride3.7%1
12
Ascorbic-acid3.7%1
13
Allopurinol3.7%1
14
Magnesium-acetate-tetrahydrate3.7%1
15
Zinc-sulfate3.7%1

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports halofantrine side effects

48.1% of halofantrine adverse event reports involve female patients and 48.1% involve male patients. The largest age group is adult at 68%. These figures reflect who reports side effects, not underlying risk.

Sex

Female48.1%
Male48.1%
Unknown3.7%

Age group

< 24.5%
2–1113.6%
12–1713.6%
18–6468.2%
65+0.0%

What is halofantrine used for

Conditions and purposes for which patients were taking halofantrine when the adverse event was reported.

MalariaMalaria ProphylaxisProduct Used For Unknown IndicationSleep Disorder

Halofantrine brand names and reporting trend

Halofantrine is sold under the brand name Halfan.

Brand names

Halfan15

Quarterly reports (20042024)

20042005201020202024

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking halofantrine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.