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Guanidine Side Effects

The most commonly reported side effects of guanidine include pulmonary pain, lower respiratory tract infection, and arthropathy, based on 178 FDA adverse event reports from 2004 to 2025.

#1 Reported: Pulmonary PainAll side effects ↓Top Co-Medication: MethotrexateDrug interactions ↓41% of Reports Are AdultDemographics ↓

Guanidine side effects

Percentages show how often each reaction appears relative to total reports for guanidine.

1
Pulmonary Pain51.1%91
2
Lower Respiratory Tract Infection51.1%91
3
Arthropathy51.1%91
4
Abdominal Discomfort50.6%90
5
Product Dose Omission Issue50.0%89
6
Rash50.0%89
7
Off Label Use49.4%88
8
Overdose47.8%85
9
Drug Abuse47.2%84
10
Intentional Product Misuse47.2%84
11
Knee Arthroplasty39.3%70
12
Obesity24.2%43
13
Condition Aggravated23.6%42
14
Amyloid Arthropathy23.0%41
15
Lung Neoplasm Malignant22.5%40

These are voluntary reports and do not establish that guanidine caused these reactions.

Report severity

89.9%Serious160 reports
56.2%Hospitalizations100 reports
29.2%Fatal52 reports

Seriousness is determined by the reporter, not by OpenClaim.

Guanidine drug interactions

Other drugs that appear in adverse event reports alongside guanidine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Methotrexate52.8%94
2
Etanercept50.6%90
3
Ciprofloxacin50.6%90
4
Omeprazole50.0%89
5
Aminophylline50.0%89
6
Cysteine-hydrochloride49.4%88
7
Venlafaxine48.9%87
8
Irbesartan48.9%87
9
Carbamazepine48.3%86
10
Zinc-sulfate-heptahydrate-cupric-sulfate-manganese-sulfate-selenious-acid36.0%64
11
Theophylline25.3%45
12
Amoxicillin23.6%42
13
Clozapine21.9%39
14
Simvastatin21.3%38
15
Tamsulosin-hydrochloride21.3%38

Taken alongside

1
Levothyroxine-sodium55.6%99
2
Ezetimibe53.9%96
3
Ketoprofen52.8%94
4
Bendroflumethiazide52.2%93
5
Cabergoline52.2%93
6
Cetirizine-hydrochloride51.7%92
7
Folic-acid42.1%75
8
Doxycycline19.1%34
9
Theophylline14.0%25
10
Duloxetine-hydrochloride11.8%21
11
Beclomethasone11.2%20
12
Aspirin5.6%10
13
Atorvastatin-calcium5.6%10
14
Amlodipine3.9%7
15
Cysteine-hydrochloride3.9%7

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports guanidine side effects

36.0% of guanidine adverse event reports involve female patients and 38.8% involve male patients. The largest age group is adult at 41%. These figures reflect who reports side effects, not underlying risk.

Sex

Female36.0%
Male38.8%
Unknown25.3%

Age group

< 25.0%
2–1112.1%
12–170.7%
18–6441.4%
65+40.7%

What is guanidine used for

Conditions and purposes for which patients were taking guanidine when the adverse event was reported.

AnxietyAbdominal DiscomfortAttention Deficit Hyperactivity DisorderBlood Pressure MeasurementChemotherapyDepressionGanglioneuroblastomaMuscular WeaknessMyasthenic SyndromeNeuroblastomaNeuroblastoma RecurrentNon-hodgkin^s LymphomaNeuroblastomaParaganglion NeoplasmProduct Used For Unknown Indication

Showing 15 of 20 indications

Guanidine brand names and reporting trend

Quarterly reports (2004–2025)

2004201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking guanidine with another medication?

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