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Guanethidine Side Effects

The most commonly reported side effects of guanethidine include arthralgia, accidental overdose, and hypertension, based on 11 FDA adverse event reports from 2004 to 2024. 9.1% of reports found the drug to be ineffective.

Guanethidine side effects

Percentages show how often each reaction appears relative to total reports for guanethidine.

1
Arthralgia18.2%2
2
Accidental Overdose9.1%1
3
Hypertension9.1%1
4
Aphasia9.1%1
5
Malaise9.1%1
6
Syncope Vasovagal9.1%1
7
Blood Pressure Inadequately Controlled9.1%1
8
Drug Ineffective9.1%1
9
Nephrolithiasis9.1%1
10
Renal Tubular Acidosis9.1%1
11
Ureteric Obstruction9.1%1
12
Viith Nerve Paralysis9.1%1
13
Chills9.1%1
14
Pyrexia9.1%1
15
Pain9.1%1

These are voluntary reports and do not establish that guanethidine caused these reactions.

Report severity

100.0%Serious11 reports
72.7%Hospitalizations8 reports
9.1%Fatal1 reports

Seriousness is determined by the reporter, not by OpenClaim.

Guanethidine drug interactions

Other drugs that appear in adverse event reports alongside guanethidine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Hydralazine-hydrochloride27.3%3
2
Lidocaine9.1%1
3
Amiloride-hydrochloride9.1%1
4
Hydrochlorothiazide9.1%1
5
Methyldopa9.1%1
6
Methyldopate-hydrochloride9.1%1
7
Diltiazem9.1%1
8
Chloroprocaine-hydrochloride9.1%1
9
Minoxidil9.1%1
10
Octreotide-acetate9.1%1

Taken alongside

1
Clonidine18.2%2
2
Propranolol-hydrochloride18.2%2
3
Quinapril-hydrochloride9.1%1
4
Formoterol9.1%1
5
Ergocalciferol9.1%1
6
Pregabalin9.1%1
7
Fexofenadine-hydrochloride9.1%1
8
Esomeprazole9.1%1
9
Zolpidem-tartrate9.1%1
10
Eszopiclone9.1%1
11
Folic-acid9.1%1
12
Aspirin9.1%1
13
Amlodipine9.1%1
14
Cyclizine-lactate9.1%1
15
Cimetidine9.1%1

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports guanethidine side effects

36.4% of guanethidine adverse event reports involve female patients and 54.5% involve male patients. The largest age group is adult at 75%. These figures reflect who reports side effects, not underlying risk.

Sex

Female36.4%
Male54.5%
Unknown9.1%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6475.0%
65+25.0%

What is guanethidine used for

Conditions and purposes for which patients were taking guanethidine when the adverse event was reported.

AngiopathyComplex Regional Pain SyndromeCrush InjuryEssential HypertensionHypertensionProduct Used For Unknown IndicationProduct Used For Unknown Indication

Guanethidine brand names and reporting trend

Guanethidine is sold under the brand name Ismelin.

Brand names

Ismelin6

Quarterly reports (20042024)

20042024

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking guanethidine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.