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Guanadrel Side Effects

The most commonly reported side effects of guanadrel include headache, fatigue, and off label use, based on 108 FDA adverse event reports from 2011 to 2025. 8.3% of reports found the drug to be ineffective.

Guanadrel side effects

Percentages show how often each reaction appears relative to total reports for guanadrel.

1
Headache13.9%15
2
Fatigue13.0%14
3
Off Label Use12.0%13
4
Pain12.0%13
5
Cataract11.1%12
6
Arthralgia11.1%12
7
Cough10.2%11
8
Pain In Extremity10.2%11
9
Nausea10.2%11
10
Vision Blurred9.3%10
11
Weight Decreased8.3%9
12
Drug Ineffective8.3%9
13
Asthenia6.5%7
14
Dry Eye6.5%7
15
Decreased Appetite6.5%7

These are voluntary reports and do not establish that guanadrel caused these reactions.

Report severity

85.2%Serious92 reports
30.6%Hospitalizations33 reports
2.8%Fatal3 reports

Seriousness is determined by the reporter, not by OpenClaim.

Guanadrel drug interactions

Other drugs that appear in adverse event reports alongside guanadrel. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Rituximab6.5%7
2
Latanoprost5.6%6
3
Adalimumab5.6%6
4
Nilotinib4.6%5
5
Prednisone4.6%5
6
Vemurafenib3.7%4
7
Atezolizumab3.7%4
8
Cobimetinib-fumarate3.7%4
9
Letrozole3.7%4
10
Anastrozole3.7%4
11
Apixaban2.8%3
12
Infliximab2.8%3
13
Abemaciclib2.8%3
14
Dexamethasone2.8%3
15
Tofacitinib2.8%3

Taken alongside

1
Pantoprazole-sodium15.7%17
2
Acetaminophen15.7%17
3
Ergocalciferol15.7%17
4
Omeprazole12.0%13
5
Aspirin11.1%12
6
Cyclosporine11.1%12
7
Folic-acid11.1%12
8
Methotrexate11.1%12
9
Ibuprofen11.1%12
10
Atorvastatin-calcium10.2%11
11
Cetirizine-hydrochloride10.2%11
12
Magnesium-acetate-tetrahydrate9.3%10
13
Levothyroxine-sodium9.3%10
14
Prednisone9.3%10
15
Rosuvastatin8.3%9

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports guanadrel side effects

67.6% of guanadrel adverse event reports involve female patients and 28.7% involve male patients. The largest age group is adult at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female67.6%
Male28.7%
Unknown3.7%

Age group

< 20.0%
2–111.1%
12–170.0%
18–6452.2%
65+46.7%

What is guanadrel used for

Conditions and purposes for which patients were taking guanadrel when the adverse event was reported.

BlepharitisCorneal AbrasionDry EyeDry EyeEpilepsyEye DisorderEye IrritationEye Lubrication TherapyEye PainEye DisorderEye Lubrication TherapyForeign Body Sensation In EyesNeovascular Age-related Macular DegenerationProduct Used For Unknown IndicationProphylaxis

Showing 15 of 17 indications

Guanadrel brand names and reporting trend

Guanadrel is sold under the brand name Hylorel.

Brand names

Hylorel2

Quarterly reports (20112025)

2011201620242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking guanadrel with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.