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Grazoprevir Side Effects

The most commonly reported side effects of grazoprevir include fatigue, headache, and nausea, based on 4,349 FDA adverse event reports from 2016 to 2025.

Grazoprevir side effects

Percentages show how often each reaction appears relative to total reports for grazoprevir.

1
Fatigue22.2%967
2
Headache17.6%764
3
Nausea12.9%563
4
Insomnia7.2%313
5
Diarrhoea6.1%264
6
Drug Dose Omission5.9%255
7
Vomiting4.3%185
8
Hepatitis C3.9%168
9
Adverse Event3.4%150
10
Pneumonia3.4%146
11
Arthralgia3.2%137
12
Pruritus3.0%132
13
Dizziness2.8%123
14
Pain2.8%121
15
Abdominal Pain2.7%119

These are voluntary reports and do not establish that grazoprevir caused these reactions.

Report severity

35.2%Serious1,532 reports
13.3%Hospitalizations580 reports
3.1%Fatal134 reports

Seriousness is determined by the reporter, not by OpenClaim.

Grazoprevir drug interactions

Other drugs that appear in adverse event reports alongside grazoprevir. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Elbasvir94.0%4,087
2
Ribavirin4.8%210
3
Infliximab2.4%106
4
Abatacept2.3%98
5
Rituximab2.2%95
6
Tocilizumab2.0%89
7
Tofacitinib2.0%89
8
Sofosbuvir2.0%88
9
Alendronate-sodium2.0%88
10
Sulfasalazine2.0%88
11
Adalimumab2.0%87
12
Methotrexate2.0%87
13
Naproxen2.0%86
14
Etanercept2.0%86
15
Leflunomide2.0%86

Taken alongside

1
Amlodipine6.6%287
2
Lisinopril6.3%273
3
Aspirin4.9%212
4
Omeprazole4.5%197
5
Acetaminophen4.5%194
6
Ibuprofen4.4%193
7
Gabapentin4.4%192
8
Ergocalciferol4.4%190
9
Elbasvir4.2%181
10
Pantoprazole-sodium3.9%170
11
Cyanocobalamin3.6%156
12
Hydrochlorothiazide3.4%147
13
Albuterol3.3%145
14
Metformin3.3%144
15
Atorvastatin-calcium3.2%137

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports grazoprevir side effects

41.2% of grazoprevir adverse event reports involve female patients and 46.6% involve male patients. The largest age group is adult at 78%. These figures reflect who reports side effects, not underlying risk.

Sex

Female41.2%
Male46.6%
Unknown12.3%

Age group

< 20.1%
2–110.0%
12–17<0.1%
18–6477.8%
65+22.0%

What is grazoprevir used for

Conditions and purposes for which patients were taking grazoprevir when the adverse event was reported.

Acute Hepatitis CAntiviral TreatmentAnxietyAnxiety DisorderArteriosclerosisArthritisAsthmaAtrial FibrillationAtrial FlutterCardiac FailureChild-pugh-turcotte Score IncreasedCholangiogram AbnormalChronic Hepatic FailureChronic HepatitisChronic Hepatitis C

Showing 15 of 82 indications

Grazoprevir brand names and reporting trend

Grazoprevir is sold under the brand name Zepatier.

Brand names

Zepatier118

Quarterly reports (20162025)

2016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking grazoprevir with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.