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Granisetron Side Effects

The most commonly reported side effects of granisetron include nausea, diarrhoea, and febrile neutropenia, based on 19,773 FDA adverse event reports from 2004 to 2025.

Granisetron side effects

Percentages show how often each reaction appears relative to total reports for granisetron.

1
Nausea9.5%1,877
2
Diarrhoea5.6%1,114
3
Febrile Neutropenia5.6%1,114
4
Vomiting5.5%1,094
5
Pyrexia5.2%1,028
6
Death5.1%1,018
7
Fatigue4.7%931
8
Dyspnoea4.3%856
9
Off Label Use4.3%851
10
Anaemia3.8%750
11
Neutropenia3.3%656
12
Decreased Appetite3.2%638
13
Constipation3.2%632
14
Pneumonia2.9%576
15
Platelet Count Decreased2.6%523

These are voluntary reports and do not establish that granisetron caused these reactions.

Report severity

88.5%Serious17,503 reports
50.3%Hospitalizations9,949 reports
21.6%Fatal4,263 reports

Seriousness is determined by the reporter, not by OpenClaim.

Granisetron drug interactions

Other drugs that appear in adverse event reports alongside granisetron. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Bevacizumab8.8%1,741
2
Paclitaxel8.7%1,720
3
Carboplatin8.6%1,700
4
Cyclophosphamide6.8%1,341
5
Oxaliplatin6.5%1,281
6
Fluorouracil6.4%1,261
7
Doxorubicin-hydrochloride6.0%1,187
8
Docetaxel5.6%1,116
9
Dexamethasone5.1%999
10
Rituximab4.6%909
11
Vincristine-sulfate4.5%895
12
Trastuzumab4.4%865
13
Irinotecan-hydrochloride3.9%771
14
Cisplatin3.8%753
15
Gemcitabine3.7%731

Taken alongside

1
Dexamethasone39.5%7,811
2
Acetaminophen17.2%3,406
3
Ondansetron10.5%2,083
4
Diphenhydramine9.7%1,913
5
Furosemide9.5%1,870
6
Metoclopramide-hydrochloride8.9%1,769
7
Pantoprazole-sodium8.8%1,746
8
Lorazepam8.3%1,643
9
Aprepitant8.3%1,633
10
Ranitidine8.0%1,574
11
Acyclovir7.6%1,505
12
Omeprazole7.4%1,459
13
Famotidine6.7%1,328
14
Oxycodone6.6%1,306
15
Allopurinol6.3%1,245

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports granisetron side effects

45.6% of granisetron adverse event reports involve female patients and 41.0% involve male patients. The largest age group is adult at 51%. These figures reflect who reports side effects, not underlying risk.

Sex

Female45.6%
Male41.0%
Unknown13.4%

Age group

< 20.7%
2–113.3%
12–173.0%
18–6450.8%
65+42.2%

What is granisetron used for

Conditions and purposes for which patients were taking granisetron when the adverse event was reported.

Abdominal DiscomfortAbdominal PainAcute LeukaemiaAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Myeloid LeukaemiaAcute Myeloid Leukaemia RecurrentAcute Promyelocytic LeukaemiaAdenocarcinomaAdjuvant TherapyAdult T-cell Lymphoma/leukaemiaAdverse Drug ReactionAdverse EventAgranulocytosisAllergy Prophylaxis

Showing 15 of 391 indications

Granisetron brand names and reporting trend

Granisetron is sold under brand names including Sustol, Granisol.

Brand names

Sustol13,956
Granisol1,730

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking granisetron with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.