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Gramicidin Side Effects

The most commonly reported side effects of gramicidin include drug hypersensitivity, infusion related reaction, and macular degeneration, based on 2,425 FDA adverse event reports from 2004 to 2025. 15.2% of reports found the drug to be ineffective.

Gramicidin side effects

Percentages show how often each reaction appears relative to total reports for gramicidin.

1
Drug Hypersensitivity21.4%519
2
Drug Ineffective15.2%369
3
Infusion Related Reaction10.3%249
4
Macular Degeneration10.2%248
5
Rash10.2%247
6
Headache9.9%240
7
Hypoaesthesia9.4%228
8
Nausea9.4%227
9
Pain9.3%226
10
Pyrexia9.2%223
11
Hypertension9.1%220
12
Weight Decreased8.9%217
13
Hypersensitivity8.9%217
14
Pruritus8.9%216
15
Fatigue8.5%207

These are voluntary reports and do not establish that gramicidin caused these reactions.

Report severity

62.0%Serious1,503 reports
22.4%Hospitalizations543 reports
19.0%Fatal460 reports

Seriousness is determined by the reporter, not by OpenClaim.

Gramicidin drug interactions

Other drugs that appear in adverse event reports alongside gramicidin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Neomycin-sulfate53.3%1,292
2
Polymyxin-b-sulfate49.7%1,205
3
Acetaminophen26.5%642
4
Adalimumab25.1%609
5
Pregabalin24.0%583
6
Cetirizine-hydrochloride23.3%565
7
Pantoprazole-sodium22.7%550
8
Prednisone22.4%544
9
Triamcinolone22.3%541
10
Diphenhydramine22.1%537
11
Mesalamine22.1%536
12
Morphine-sulfate20.4%494
13
Calcium-carbonate18.1%439
14
Calcium17.1%414
15
Hydrocortisone16.7%406

Taken alongside

1
Neomycin-sulfate30.9%750
2
Polymyxin-b-sulfate29.9%725
3
Acetaminophen16.0%389
4
Ergocalciferol10.5%254
5
Diphenhydramine8.9%215
6
Valsartan7.8%189
7
Aspirin7.4%180
8
Levothyroxine-sodium6.6%161
9
Pantoprazole-sodium6.5%158
10
Lisinopril6.3%153
11
Calcium6.3%153
12
Prednisone6.0%146
13
Oxycodone5.9%144
14
Hydrocortisone5.9%143
15
Lorazepam5.5%134

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports gramicidin side effects

72.2% of gramicidin adverse event reports involve female patients and 17.5% involve male patients. The largest age group is adult at 55%. These figures reflect who reports side effects, not underlying risk.

Sex

Female72.2%
Male17.5%
Unknown10.3%

Age group

< 20.9%
2–111.5%
12–171.4%
18–6455.3%
65+40.9%

What is gramicidin used for

Conditions and purposes for which patients were taking gramicidin when the adverse event was reported.

AbscessAcanthamoeba KeratitisAccidental ExposureAccidental Exposure To ProductAccidental Exposure To Product By ChildAcneAdverse EventAdverse ReactionAnalgesic EffectAnalgesic TherapyAnimal BiteAnimal ScratchAnti-infective TherapyAntibiotic ProphylaxisAntibiotic Therapy

Showing 15 of 214 indications

Gramicidin brand names and reporting trend

Gramicidin is sold under the brand name Neo-polycin.

Brand names

Neo-polycin764

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking gramicidin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.