OpenClaim

Goserelin Side Effects

The most commonly reported side effects of goserelin include death, malignant neoplasm progression, and fatigue, based on 14,218 FDA adverse event reports from 2004 to 2025. 2.4% of reports found the drug to be ineffective.

Goserelin side effects

Percentages show how often each reaction appears relative to total reports for goserelin.

1
Death11.5%1,632
2
Malignant Neoplasm Progression9.5%1,347
3
Fatigue5.7%809
4
Metastases To Bone4.7%663
5
Neutropenia4.3%611
6
Nausea3.6%511
7
Off Label Use3.4%488
8
Asthenia3.2%461
9
Diarrhoea3.2%453
10
Metastases To Liver3.1%441
11
Hot Flush3.0%424
12
Pain2.9%415
13
Arthralgia2.7%377
14
Dyspnoea2.5%360
15
Anaemia2.5%353

These are voluntary reports and do not establish that goserelin caused these reactions.

Report severity

90.8%Serious12,916 reports
31.2%Hospitalizations4,440 reports
18.9%Fatal2,683 reports

Seriousness is determined by the reporter, not by OpenClaim.

Goserelin drug interactions

Other drugs that appear in adverse event reports alongside goserelin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Letrozole12.6%1,796
2
Bicalutamide7.3%1,039
3
Ribociclib7.1%1,009
4
Zoledronic-acid6.8%973
5
Docetaxel6.7%955
6
Palbociclib6.6%943
7
Tamoxifen-citrate6.6%940
8
Fulvestrant5.3%756
9
Denosumab5.3%749
10
Enzalutamide5.1%732
11
Trastuzumab5.1%726
12
Abiraterone-acetate4.9%694
13
Capecitabine3.6%514
14
Paclitaxel3.3%472
15
Anastrozole3.2%461

Taken alongside

1
Acetaminophen5.9%836
2
Letrozole4.9%690
3
Aspirin4.7%668
4
Denosumab4.6%658
5
Zoledronic-acid4.5%637
6
Bicalutamide4.1%584
7
Ergocalciferol3.9%548
8
Omeprazole3.6%506
9
Amlodipine3.3%471
10
Dexamethasone3.3%470
11
Atorvastatin-calcium3.1%434
12
Tamoxifen-citrate3.0%426
13
Calcium3.0%420
14
Prednisone2.9%416
15
Docetaxel2.7%382

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports goserelin side effects

33.1% of goserelin adverse event reports involve female patients and 44.4% involve male patients. The largest age group is adult at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female33.1%
Male44.4%
Unknown22.5%

Age group

< 2<0.1%
2–110.2%
12–17<0.1%
18–6451.9%
65+47.8%

What is goserelin used for

Conditions and purposes for which patients were taking goserelin when the adverse event was reported.

Abdominal PainAbdominal Pain LowerAdenocarcinomaAdenomyosisAdjuvant TherapyAdnexa Uteri PainAdverse EventAnaemiaAndrogen TherapyAngiomyxomaAntiandrogen TherapyAntioestrogen TherapyAphthous UlcerArtificial MenopauseAssisted Fertilisation

Showing 15 of 372 indications

Goserelin brand names and reporting trend

Goserelin is sold under the brand name Zoladex.

Brand names

Zoladex6,549

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking goserelin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.