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Gonadotropin Side Effects

The most commonly reported side effects of gonadotropin include ovarian hyperstimulation syndrome, no adverse event, and ovarian hyperstimulation syndrome, based on 2,019 FDA adverse event reports from 2004 to 2025. 5.5% of reports found the drug to be ineffective.

Gonadotropin side effects

Percentages show how often each reaction appears relative to total reports for gonadotropin.

1
Ovarian Hyperstimulation Syndrome12.6%254
2
No Adverse Event10.4%210
3
Ovarian Hyperstimulation Syndrome5.5%112
4
Drug Ineffective5.5%111
5
Product Dose Omission Issue5.3%106
6
Off Label Use4.2%85
7
Inappropriate Schedule Of Drug Administration4.2%85
8
Product Packaging Quantity Issue4.0%81
9
Product Quality Issue3.9%79
10
Product Dose Omission3.7%74
11
Product Use In Unapproved Indication3.5%71
12
Drug Exposure During Pregnancy3.1%62
13
Headache2.9%58
14
Injection Site Pain2.8%56
15
Maternal Exposure Before Pregnancy2.6%53

These are voluntary reports and do not establish that gonadotropin caused these reactions.

Report severity

48.6%Serious981 reports
24.3%Hospitalizations491 reports
2.3%Fatal46 reports

Seriousness is determined by the reporter, not by OpenClaim.

Gonadotropin drug interactions

Other drugs that appear in adverse event reports alongside gonadotropin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Follitropin-alfa-beta14.7%297
2
Sterile10.7%216
3
Menotropins-fsh9.4%190
4
Ganirelix-acetate6.5%132
5
Progesterone6.1%123
6
Leuprolide3.7%74
7
Carbamazepine3.5%71
8
Cetrorelix-acetate2.6%52
9
Urofollitropin2.2%44
10
Letrozole1.9%38
11
Clomiphene-citrate1.6%33
12
Testosterone1.6%32
13
Estradiol1.5%30
14
Somatropin1.3%27
15
Sodium-oxybate0.9%19

Taken alongside

1
Menotropins-fsh12.4%251
2
Ganirelix-acetate9.3%187
3
Follitropin-alfa-beta7.9%159
4
Progesterone7.3%147
5
Leuprolide6.0%122
6
Testosterone5.0%101
7
Estradiol4.1%83
8
Levothyroxine-sodium3.9%78
9
Doxycycline2.5%51
10
Ergocalciferol2.3%47
11
Aspirin2.2%45
12
Clomiphene-citrate2.1%43
13
Anastrozole2.1%43
14
Folic-acid2.0%41
15
Azithromycin2.0%40

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports gonadotropin side effects

66.6% of gonadotropin adverse event reports involve female patients and 26.3% involve male patients. The largest age group is adult at 93%. These figures reflect who reports side effects, not underlying risk.

Sex

Female66.6%
Male26.3%
Unknown7.1%

Age group

< 21.9%
2–110.5%
12–171.2%
18–6493.1%
65+3.3%

What is gonadotropin used for

Conditions and purposes for which patients were taking gonadotropin when the adverse event was reported.

AmenorrhoeaAndrogen DeficiencyAndrogen Replacement TherapyAnovulatory CycleAntepartum HaemorrhageArtificial InseminationArtificial Insemination By PartnerAssisted FertilisationAssisted Reproductive TechnologyAzoospermiaAcute Graft Versus Host DiseaseAcute Graft Versus Host Disease In SkinAdverse Drug ReactionAndrogen DeficiencyAnovulatory Cycle

Showing 15 of 156 indications

Gonadotropin brand names and reporting trend

Gonadotropin is sold under the brand name Pregnyl.

Brand names

Pregnyl27

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking gonadotropin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.