OpenClaim

Gonadorelin Side Effects

The most commonly reported side effects of gonadorelin include neutropenia, metastases to bone, and malignant neoplasm progression, based on 309 FDA adverse event reports from 2008 to 2025. 3.9% of reports found the drug to be ineffective.

Gonadorelin side effects

Percentages show how often each reaction appears relative to total reports for gonadorelin.

1
Neutropenia14.2%44
2
Metastases To Bone10.4%32
3
Malignant Neoplasm Progression9.4%29
4
Nausea7.4%23
5
Diarrhoea7.4%23
6
Asthenia6.5%20
7
White Blood Cell Count Decreased5.8%18
8
Headache5.2%16
9
Hot Flush5.2%16
10
Breast Cancer4.9%15
11
Ovarian Hyperstimulation Syndrome4.9%15
12
Carcinoembryonic Antigen Increased4.9%15
13
Pyrexia4.9%15
14
Fatigue4.5%14
15
Hypertension4.2%13

These are voluntary reports and do not establish that gonadorelin caused these reactions.

Report severity

95.8%Serious296 reports
35.9%Hospitalizations111 reports
6.8%Fatal21 reports

Seriousness is determined by the reporter, not by OpenClaim.

Gonadorelin drug interactions

Other drugs that appear in adverse event reports alongside gonadorelin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Letrozole21.0%65
2
Ribociclib17.8%55
3
Abiraterone-acetate13.6%42
4
Apalutamide11.3%35
5
Tamoxifen-citrate9.1%28
6
Fulvestrant7.8%24
7
Docetaxel7.4%23
8
Zoledronic-acid7.1%22
9
Palbociclib7.1%22
10
Denosumab6.1%19
11
Capecitabine5.2%16
12
Bicalutamide4.5%14
13
Anastrozole4.2%13
14
Leuprolide3.6%11
15
Progesterone3.6%11

Taken alongside

1
Prednisolone8.4%26
2
Bisoprolol-fumarate5.5%17
3
Omeprazole5.2%16
4
Acetaminophen5.2%16
5
Prednisone4.9%15
6
Metformin4.9%15
7
Aspirin4.2%13
8
Bicalutamide3.9%12
9
Atorvastatin-calcium3.6%11
10
Zoledronic-acid3.2%10
11
Levothyroxine-sodium3.2%10
12
Denosumab3.2%10
13
Amlodipine2.9%9
14
Insulin2.9%9
15
Dexamethasone2.6%8

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports gonadorelin side effects

42.1% of gonadorelin adverse event reports involve female patients and 52.1% involve male patients. The largest age group is adult at 60%. These figures reflect who reports side effects, not underlying risk.

Sex

Female42.1%
Male52.1%
Unknown5.8%

Age group

< 20.4%
2–112.0%
12–170.0%
18–6459.8%
65+37.8%

What is gonadorelin used for

Conditions and purposes for which patients were taking gonadorelin when the adverse event was reported.

Assisted Reproductive TechnologyAdenocarcinomaAndrogen Replacement TherapyAntiandrogen TherapyAssisted Reproductive TechnologyBreast CancerBreast Cancer MetastaticBlood Testosterone DecreasedBreast CancerBreast Cancer MetastaticBreast Cancer Stage IiiControlled Ovarian StimulationDiagnostic ProcedureDrug Use For Unknown IndicationEndometriosis

Showing 15 of 47 indications

Gonadorelin brand names and reporting trend

Gonadorelin is sold under brand names including Factrel, Lutrepulse Kit.

Brand names

Factrel332
Lutrepulse Kit25

Quarterly reports (20082025)

2008201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking gonadorelin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.