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Golimumab Side Effects

The most commonly reported side effects of golimumab include rheumatoid arthritis, pain, and fatigue, based on 82,692 FDA adverse event reports from 2008 to 2025. 25.4% of reports found the drug to be ineffective.

Golimumab side effects

Percentages show how often each reaction appears relative to total reports for golimumab.

1
Drug Ineffective25.4%21,001
2
Rheumatoid Arthritis17.0%14,045
3
Pain16.1%13,351
4
Fatigue13.6%11,225
5
Off Label Use12.1%9,974
6
Joint Swelling11.7%9,714
7
Arthralgia11.7%9,635
8
Rash11.2%9,278
9
Alopecia11.2%9,266
10
Drug Intolerance10.6%8,790
11
Abdominal Discomfort10.5%8,664
12
Swelling10.2%8,459
13
Systemic Lupus Erythematosus10.1%8,322
14
Contraindicated Product Administered10.0%8,258
15
Pemphigus9.8%8,083

These are voluntary reports and do not establish that golimumab caused these reactions.

Report severity

75.1%Serious62,100 reports
23.8%Hospitalizations19,711 reports
7.2%Fatal5,921 reports

Seriousness is determined by the reporter, not by OpenClaim.

Golimumab drug interactions

Other drugs that appear in adverse event reports alongside golimumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Methotrexate28.2%23,298
2
Etanercept26.0%21,491
3
Adalimumab23.6%19,542
4
Abatacept23.2%19,201
5
Leflunomide21.8%18,019
6
Tocilizumab20.9%17,245
7
Infliximab20.3%16,824
8
Hydroxychloroquine-sulfate19.6%16,179
9
Certolizumab-pegol19.4%16,014
10
Rituximab18.7%15,490
11
Sulfasalazine17.3%14,275
12
Prednisone14.5%12,016
13
Tofacitinib12.8%10,574
14
Folic-acid12.5%10,301
15
Alendronate-sodium12.4%10,277

Taken alongside

1
Methotrexate10.4%8,628
2
Prednisone9.9%8,197
3
Acetaminophen8.3%6,889
4
Sulfasalazine7.4%6,081
5
Tofacitinib7.2%5,980
6
Pantoprazole-sodium7.2%5,954
7
Ibuprofen7.0%5,825
8
Folic-acid5.8%4,823
9
Hydroxychloroquine-sulfate5.4%4,500
10
Ergocalciferol5.4%4,446
11
Leflunomide5.3%4,423
12
Desogestrel3.9%3,216
13
Ethinyl-estradiol3.8%3,124
14
Diclofenac3.6%3,013
15
Adalimumab3.6%3,002

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports golimumab side effects

67.2% of golimumab adverse event reports involve female patients and 20.5% involve male patients. The largest age group is adult at 73%. These figures reflect who reports side effects, not underlying risk.

Sex

Female67.2%
Male20.5%
Unknown12.2%

Age group

< 20.3%
2–110.3%
12–170.5%
18–6473.5%
65+25.4%

What is golimumab used for

Conditions and purposes for which patients were taking golimumab when the adverse event was reported.

Accidental ExposureAccidental Exposure To ProductAccidental Exposure To Product By ChildAnal PolypAnalgesic TherapyAnkylosing SpondylitisArthralgiaArthritisArthritis BacterialArthritis EnteropathicArthritis ReactiveArthropathyAsthmaAttention Deficit/hyperactivity DisorderAutoimmune Arthritis

Showing 15 of 361 indications

Golimumab brand names and reporting trend

Golimumab is sold under the brand name Simponi.

Brand names

Simponi15,700

Quarterly reports (20082025)

2010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking golimumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.