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Glycopyrrolate Side Effects

The most commonly reported side effects of glycopyrrolate include dyspnoea, cough, and death, based on 20,025 FDA adverse event reports from 2004 to 2025. 6.5% of reports found the drug to be ineffective.

Glycopyrrolate side effects

Percentages show how often each reaction appears relative to total reports for glycopyrrolate.

1
Dyspnoea18.5%3,713
2
Cough9.5%1,897
3
Death8.9%1,775
4
Device Delivery System Issue7.5%1,501
5
Product Dose Omission Issue7.2%1,451
6
Asthma7.1%1,430
7
Drug Ineffective6.5%1,305
8
Wrong Technique In Device Usage Process6.5%1,303
9
Pneumonia5.8%1,152
10
Chronic Obstructive Pulmonary Disease5.7%1,143
11
Device Use Issue5.6%1,116
12
Wheezing5.0%1,009
13
Off Label Use4.8%966
14
Device Malfunction4.5%904
15
Fatigue4.4%873

These are voluntary reports and do not establish that glycopyrrolate caused these reactions.

Report severity

56.6%Serious11,343 reports
23.8%Hospitalizations4,772 reports
12.8%Fatal2,568 reports

Seriousness is determined by the reporter, not by OpenClaim.

Glycopyrrolate drug interactions

Other drugs that appear in adverse event reports alongside glycopyrrolate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Formoterol41.7%8,352
2
Budesonide36.0%7,209
3
Albuterol4.7%936
4
Dupilumab4.3%856
5
Fluticasone3.5%708
6
Mepolizumab3.3%660
7
Prednisone3.3%653
8
Montelukast-sodium2.6%528
9
Omalizumab2.4%490
10
Tiotropium-bromide2.3%453
11
Treprostinil2.1%428
12
Vilanterol-trifenatate1.9%377
13
Ipratropium-bromide1.9%374
14
Ciclesonide1.6%329
15
Fentanyl1.6%318

Taken alongside

1
Albuterol18.8%3,764
2
Formoterol16.7%3,351
3
Budesonide16.3%3,255
4
Acetaminophen9.3%1,867
5
Fluticasone7.8%1,553
6
Ergocalciferol7.6%1,515
7
Montelukast-sodium7.3%1,457
8
Aspirin7.1%1,423
9
Omeprazole6.5%1,296
10
Furosemide6.3%1,258
11
Prednisone6.1%1,230
12
Atorvastatin-calcium5.8%1,170
13
Levothyroxine-sodium5.5%1,094
14
Pantoprazole-sodium5.3%1,062
15
Gabapentin5.3%1,055

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports glycopyrrolate side effects

48.9% of glycopyrrolate adverse event reports involve female patients and 35.8% involve male patients. The largest age group is elderly at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female48.9%
Male35.8%
Unknown15.3%

Age group

< 21.6%
2–113.6%
12–171.8%
18–6441.2%
65+51.8%

What is glycopyrrolate used for

Conditions and purposes for which patients were taking glycopyrrolate when the adverse event was reported.

Abdominal DiscomfortAbdominal PainAbdominal Pain UpperAirway Secretion Clearance TherapyAlpha-1 Anti-trypsin DeficiencyAmyotrophic Lateral SclerosisAnaesthesiaAnaesthesia ProcedureAnaesthesia ReversalAnaesthetic PremedicationAnaphylactic ReactionAnkylosing SpondylitisAntacid TherapyAntibiotic ProphylaxisAntibiotic Therapy

Showing 15 of 415 indications

Glycopyrrolate brand names and reporting trend

Glycopyrrolate is sold under the brand name Robinul.

Brand names

Robinul6,579

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking glycopyrrolate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.