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Glycerol Side Effects

The most commonly reported side effects of glycerol include vomiting, ammonia increased, and hyperammonaemia, based on 2,040 FDA adverse event reports from 2004 to 2025. 3.2% of reports found the drug to be ineffective.

Glycerol side effects

Percentages show how often each reaction appears relative to total reports for glycerol.

1
Vomiting10.5%214
2
Ammonia Increased9.3%189
3
Hyperammonaemia7.5%154
4
Decreased Appetite6.2%126
5
Nausea6.0%122
6
Headache4.9%99
7
Off Label Use4.3%87
8
Diarrhoea4.0%81
9
Constipation3.6%74
10
Fatigue3.5%71
11
Malaise3.3%68
12
Drug Ineffective3.2%65
13
Hyperammonaemic Crisis3.2%65
14
Cough3.0%61
15
Somnolence2.8%58

These are voluntary reports and do not establish that glycerol caused these reactions.

Report severity

72.1%Serious1,471 reports
47.0%Hospitalizations959 reports
8.8%Fatal180 reports

Seriousness is determined by the reporter, not by OpenClaim.

Glycerol drug interactions

Other drugs that appear in adverse event reports alongside glycerol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Morphine-sulfate3.8%77
2
Acetaminophen3.3%67
3
Amlodipine3.0%62
4
Furosemide3.0%62
5
Bisacodyl2.9%59
6
Prednisone2.6%54
7
Trastuzumab2.5%50
8
Pregabalin2.3%46
9
Carbamazepine2.2%45
10
Atorvastatin-calcium2.2%44
11
Nitroglycerin2.2%44
12
Amitriptyline-hydrochloride2.2%44
13
Capecitabine2.1%42
14
Omeprazole2.1%42
15
Sodium-phenylbutyrate2.1%42

Taken alongside

1
Acetaminophen12.8%261
2
Omeprazole9.5%193
3
Lactulose8.1%166
4
Arginine-hydrochloride6.9%141
5
Aspirin6.8%139
6
Lansoprazole6.5%132
7
Albuterol5.6%115
8
Furosemide5.6%114
9
Sodium-benzoate4.3%87
10
Ondansetron4.2%85
11
Levothyroxine-sodium3.9%79
12
Ergocalciferol3.8%78
13
Dexamethasone3.8%77
14
Metoclopramide-hydrochloride3.7%75
15
Levetiracetam3.6%74

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports glycerol side effects

51.1% of glycerol adverse event reports involve female patients and 34.8% involve male patients. The largest age group is adult at 40%. These figures reflect who reports side effects, not underlying risk.

Sex

Female51.1%
Male34.8%
Unknown14.1%

Age group

< 28.8%
2–1118.7%
12–178.9%
18–6439.8%
65+23.7%

What is glycerol used for

Conditions and purposes for which patients were taking glycerol when the adverse event was reported.

Abdominal PainAmino Acid Metabolism DisorderAmmonia IncreasedAnaplastic AstrocytomaArginase DeficiencyArgininosuccinate Lyase DeficiencyArgininosuccinate Synthetase DeficiencyAllan-herndon-dudley SyndromeAmino Acid Metabolism DisorderAmmonia IncreasedArginase DeficiencyArgininosuccinate Lyase DeficiencyArgininosuccinate Synthetase DeficiencyAspartate-glutamate-transporter DeficiencyBlood Magnesium Decreased

Showing 15 of 113 indications

Glycerol brand names and reporting trend

Glycerol is sold under the brand name Ravicti.

Brand names

Ravicti844

Quarterly reports (20042025)

20042010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking glycerol with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.