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Glyburide Side Effects

The most commonly reported side effects of glyburide include blood glucose increased, nausea, and weight decreased, based on 30,957 FDA adverse event reports from 2004 to 2025. 2.9% of reports found the drug to be ineffective.

Glyburide side effects

Percentages show how often each reaction appears relative to total reports for glyburide.

1
Blood Glucose Increased9.5%2,931
2
Nausea6.3%1,958
3
Weight Decreased4.7%1,458
4
Blood Glucose Decreased4.2%1,289
5
Blood Glucose Increased3.9%1,195
6
Hypoglycaemia3.2%990
7
Myocardial Infarction3.1%958
8
Dizziness3.1%956
9
Drug Ineffective2.9%909
10
Vomiting2.8%872
11
Drug Ineffective2.8%863
12
Decreased Appetite2.8%862
13
Diarrhoea2.7%841
14
Dyspnoea2.6%798
15
Nausea2.6%796

These are voluntary reports and do not establish that glyburide caused these reactions.

Report severity

62.2%Serious19,267 reports
33.9%Hospitalizations10,503 reports
9.2%Fatal2,851 reports

Seriousness is determined by the reporter, not by OpenClaim.

Glyburide drug interactions

Other drugs that appear in adverse event reports alongside glyburide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Exenatide-synthetic14.6%4,508
2
Metformin9.3%2,883
3
Rosiglitazone-maleate5.4%1,660
4
Insulin3.9%1,220
5
Pioglitazone-hydrochloride3.4%1,046
6
Sitagliptin3.0%930
7
Adalimumab2.4%757
8
Lenalidomide2.1%660
9
Omeprazole2.0%627
10
Esomeprazole1.9%588
11
Atorvastatin-calcium1.7%533
12
Rofecoxib1.5%474
13
Quetiapine-fumarate1.4%445
14
Hydrochlorothiazide1.3%408
15
Pantoprazole-sodium1.3%407

Taken alongside

1
Metformin51.4%15,923
2
Aspirin19.4%6,006
3
Insulin16.5%5,100
4
Lisinopril16.1%4,992
5
Furosemide13.6%4,200
6
Atorvastatin-calcium12.7%3,917
7
Metoprolol11.9%3,676
8
Simvastatin11.7%3,625
9
Acetaminophen10.3%3,202
10
Amlodipine10.2%3,172
11
Hydrochlorothiazide10.1%3,130
12
Levothyroxine-sodium9.4%2,904
13
Pioglitazone-hydrochloride7.4%2,286
14
Omeprazole7.4%2,281
15
Gabapentin6.7%2,061

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports glyburide side effects

47.1% of glyburide adverse event reports involve female patients and 47.9% involve male patients. The largest age group is elderly at 50%. These figures reflect who reports side effects, not underlying risk.

Sex

Female47.1%
Male47.9%
Unknown5.0%

Age group

< 20.3%
2–110.1%
12–17<0.1%
18–6449.7%
65+49.9%

What is glyburide used for

Conditions and purposes for which patients were taking glyburide when the adverse event was reported.

Accidental ExposureAccidental Exposure To ProductAccidental PoisoningAcute Kidney InjuryAccidental Exposure To Product By ChildAnxietyArthritisBlood CholesterolBlood Cholesterol IncreasedBlood GlucoseBlood Glucose AbnormalBlood Glucose DecreasedBlood Glucose FluctuationBlood Glucose IncreasedBlood Insulin

Showing 15 of 121 indications

Glyburide brand names and reporting trend

Glyburide is sold under the brand name Micronase.

Brand names

Micronase25,218

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking glyburide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.