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Glutathione Side Effects

The most commonly reported side effects of glutathione include off label use, nausea, and endophthalmitis, based on 2,119 FDA adverse event reports from 2004 to 2025.

Glutathione side effects

Percentages show how often each reaction appears relative to total reports for glutathione.

1
Off Label Use6.4%136
2
Nausea5.2%111
3
Endophthalmitis5.0%106
4
Platelet Count Decreased4.8%102
5
Fatigue4.7%99
6
Hepatic Function Abnormal4.6%97
7
Anaemia4.4%93
8
White Blood Cell Count Decreased3.9%83
9
Pyrexia3.9%82
10
Diarrhoea3.8%81
11
Headache3.8%81
12
Wrong Technique In Product Usage Process3.6%77
13
Pain3.5%75
14
Pneumonia3.4%72
15
Alanine Aminotransferase Increased3.3%70

These are voluntary reports and do not establish that glutathione caused these reactions.

Report severity

82.5%Serious1,749 reports
39.0%Hospitalizations826 reports
9.2%Fatal194 reports

Seriousness is determined by the reporter, not by OpenClaim.

Glutathione drug interactions

Other drugs that appear in adverse event reports alongside glutathione. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sodium-chloride17.5%370
2
Dextrose16.6%351
3
Sodium-bicarbonate16.4%348
4
Potassium-chloride16.3%345
5
Calcium-chloride16.2%343
6
Magnesium-chloride16.2%343
7
Sodium-phosphate16.1%342
8
Prednisone4.9%103
9
Cyclophosphamide4.8%101
10
Sodium-oxybate3.9%82
11
Trastuzumab3.7%78
12
Carboplatin3.5%75
13
Methylprednisolone3.4%72
14
Rituximab3.2%68
15
Dexamethasone3.0%63

Taken alongside

1
Dexamethasone15.3%324
2
Ergocalciferol14.7%311
3
Ascorbic-acid14.6%309
4
Omeprazole12.6%266
5
Potassium-chloride12.0%254
6
Sodium-chloride11.6%246
7
Furosemide10.9%232
8
Acetaminophen9.6%203
9
Sodium-bicarbonate8.7%184
10
Ondansetron8.4%177
11
Diphenhydramine7.9%168
12
Epinephrine7.6%161
13
Cyanocobalamin7.3%154
14
Promethazine-hydrochloride7.0%148
15
Methylprednisolone6.7%143

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports glutathione side effects

47.3% of glutathione adverse event reports involve female patients and 40.1% involve male patients. The largest age group is adult at 59%. These figures reflect who reports side effects, not underlying risk.

Sex

Female47.3%
Male40.1%
Unknown12.6%

Age group

< 20.7%
2–113.0%
12–171.8%
18–6458.7%
65+35.8%

What is glutathione used for

Conditions and purposes for which patients were taking glutathione when the adverse event was reported.

Acute Hepatic FailureAcute Myeloid LeukaemiaAlanine Aminotransferase IncreasedAnaemiaAntioxidant TherapyAscitesAspartate Aminotransferase IncreasedAtrial FibrillationAutoimmune HepatitisAcute Kidney InjuryAdjuvant TherapyAdverse Drug ReactionAdverse EventAlanine Aminotransferase IncreasedAlcoholism

Showing 15 of 180 indications

Glutathione brand names and reporting trend

Glutathione is sold under the brand name Methotrexate Sodium.

Brand names

Methotrexate Sodium2,124

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking glutathione with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.