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Gluconolactone Side Effects

The most commonly reported side effects of gluconolactone include urinary tract infection, nephrolithiasis, and cardio-respiratory arrest, based on 27 FDA adverse event reports from 2006 to 2025. 3.7% of reports found the drug to be ineffective.

Gluconolactone side effects

Percentages show how often each reaction appears relative to total reports for gluconolactone.

1
Urinary Tract Infection14.8%4
2
Nephrolithiasis11.1%3
3
Cardio-respiratory Arrest7.4%2
4
Device Failure7.4%2
5
Haematuria7.4%2
6
Septic Shock7.4%2
7
Death7.4%2
8
Fall7.4%2
9
Fatigue7.4%2
10
Diarrhoea7.4%2
11
Hepatic Function Abnormal7.4%2
12
Drug Ineffective3.7%1
13
Headache3.7%1
14
Pulmonary Arterial Pressure Increased3.7%1
15
Oxygen Saturation Decreased3.7%1

These are voluntary reports and do not establish that gluconolactone caused these reactions.

Report severity

85.2%Serious23 reports
55.6%Hospitalizations15 reports
22.2%Fatal6 reports

Seriousness is determined by the reporter, not by OpenClaim.

Gluconolactone drug interactions

Other drugs that appear in adverse event reports alongside gluconolactone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Natalizumab14.8%4
2
Nitric-oxide7.4%2
3
Citric-acid7.4%2
4
Magnesium-carbonate7.4%2
5
Ritonavir7.4%2
6
Gabapentin3.7%1
7
Hydrocodone3.7%1
8
Tolterodine-tartrate3.7%1
9
Estrogens3.7%1
10
Somatropin3.7%1
11
Dimethyl3.7%1
12
Ambrisentan3.7%1
13
Glatiramer-acetate3.7%1
14
Droxidopa3.7%1
15
Bosentan3.7%1

Taken alongside

1
Citric-acid77.8%21
2
Magnesium-carbonate77.8%21
3
Baclofen29.6%8
4
Acetaminophen29.6%8
5
Levothyroxine-sodium18.5%5
6
Fluticasone18.5%5
7
Albuterol18.5%5
8
Ergocalciferol18.5%5
9
Gabapentin18.5%5
10
Ibuprofen14.8%4
11
Potassium-chloride14.8%4
12
Omeprazole14.8%4
13
Oxycodone11.1%3
14
Pantoprazole-sodium11.1%3
15
Aspirin11.1%3

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports gluconolactone side effects

48.1% of gluconolactone adverse event reports involve female patients and 48.1% involve male patients. The largest age group is adult at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female48.1%
Male48.1%
Unknown3.7%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6457.1%
65+42.9%

What is gluconolactone used for

Conditions and purposes for which patients were taking gluconolactone when the adverse event was reported.

Bladder IrrigationDrug Use For Unknown IndicationNephrolithiasisProduct Used For Unknown IndicationProduct Used For Unknown IndicationProphylaxis

Gluconolactone brand names and reporting trend

Gluconolactone is sold under the brand name Renacidin.

Brand names

Renacidin5

Quarterly reports (20062025)

20062025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking gluconolactone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.