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Glucarpidase Side Effects

The most commonly reported side effects of glucarpidase include off label use, underdose, and laboratory test interference, based on 342 FDA adverse event reports from 2007 to 2025. 8.5% of reports found the drug to be ineffective.

Glucarpidase side effects

Percentages show how often each reaction appears relative to total reports for glucarpidase.

1
Off Label Use24.3%83
2
Underdose18.1%62
3
Laboratory Test Interference15.8%54
4
Acute Kidney Injury10.2%35
5
Toxicity To Various Agents9.6%33
6
Drug Effect Incomplete9.6%33
7
Blood Creatinine Increased9.1%31
8
Drug Ineffective8.5%29
9
Rebound Effect8.2%28
10
Renal Failure7.3%25
11
Mucosal Inflammation5.8%20
12
Death5.8%20
13
Pancytopenia4.4%15
14
False Positive Investigation Result4.4%15
15
No Adverse Event4.1%14

These are voluntary reports and do not establish that glucarpidase caused these reactions.

Report severity

71.1%Serious243 reports
23.4%Hospitalizations80 reports
17.5%Fatal60 reports

Seriousness is determined by the reporter, not by OpenClaim.

Glucarpidase drug interactions

Other drugs that appear in adverse event reports alongside glucarpidase. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Methotrexate54.4%186
2
Levoleucovorin7.6%26
3
Rituximab6.7%23
4
Vincristine-sulfate6.4%22
5
Prednisone5.0%17
6
Cyclophosphamide4.7%16
7
Furosemide4.7%16
8
Doxorubicin-hydrochloride4.4%15
9
Pantoprazole-sodium4.4%15
10
Amphotericin-b4.4%15
11
Heparin4.4%15
12
Meropenem4.1%14
13
Escitalopram-oxalate4.1%14
14
Ondansetron4.1%14
15
Lidocaine4.1%14

Taken alongside

1
Methotrexate22.5%77
2
Levoleucovorin19.6%67
3
Sodium-bicarbonate7.9%27
4
Dexamethasone6.4%22
5
Rituximab6.1%21
6
Ondansetron4.4%15
7
Oxycodone3.5%12
8
Furosemide3.5%12
9
Doxorubicin-hydrochloride3.2%11
10
Lorazepam3.2%11
11
Cytarabine2.6%9
12
Vincristine-sulfate2.6%9
13
Famotidine2.6%9
14
Aprepitant2.6%9
15
Acetaminophen2.6%9

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports glucarpidase side effects

26.6% of glucarpidase adverse event reports involve female patients and 42.4% involve male patients. The largest age group is adult at 47%. These figures reflect who reports side effects, not underlying risk.

Sex

Female26.6%
Male42.4%
Unknown31.0%

Age group

< 20.0%
2–1111.8%
12–1715.5%
18–6446.8%
65+25.9%

What is glucarpidase used for

Conditions and purposes for which patients were taking glucarpidase when the adverse event was reported.

Accidental OverdoseAcute Kidney InjuryBlood Creatinine IncreasedChemotherapyChronic Myeloid LeukaemiaChronic Myelomonocytic LeukaemiaCreatinine Renal Clearance IncreasedCrystal NephropathyCentral Nervous System LymphomaDrug Clearance DecreasedDrug LevelDrug Level IncreasedDrug TherapyDrug ToxicityDrug Toxicity Prophylaxis

Showing 15 of 31 indications

Glucarpidase brand names and reporting trend

Glucarpidase is sold under the brand name Voraxaze.

Brand names

Voraxaze58

Quarterly reports (20072025)

2007201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking glucarpidase with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.