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Glofitamab Side Effects

The most commonly reported side effects of glofitamab include cytokine release syndrome, disease progression, and death, based on 1,843 FDA adverse event reports from 2021 to 2025. 4.1% of reports found the drug to be ineffective.

Glofitamab side effects

Percentages show how often each reaction appears relative to total reports for glofitamab.

1
Cytokine Release Syndrome31.4%579
2
Disease Progression17.6%325
3
Death13.2%244
4
Off Label Use12.6%233
5
Neutropenia8.8%163
6
Pyrexia8.8%162
7
Febrile Neutropenia5.0%93
8
Covid-195.0%93
9
Immune Effector Cell-associated Neurotoxicity Syndrome4.6%85
10
Infection4.5%83
11
Anaemia4.2%78
12
Drug Ineffective4.1%76
13
Pneumonia3.9%72
14
No Adverse Event3.0%55
15
Thrombocytopenia2.9%54

These are voluntary reports and do not establish that glofitamab caused these reactions.

Report severity

89.3%Serious1,646 reports
34.1%Hospitalizations629 reports
31.1%Fatal573 reports

Seriousness is determined by the reporter, not by OpenClaim.

Glofitamab drug interactions

Other drugs that appear in adverse event reports alongside glofitamab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Obinutuzumab32.9%606
2
Rituximab29.3%540
3
Cyclophosphamide23.9%441
4
Doxorubicin-hydrochloride23.4%432
5
Vincristine-sulfate18.4%340
6
Prednisone16.8%309
7
Polatuzumab-vedotin-piiq15.2%280
8
Gemcitabine9.5%175
9
Dexamethasone8.7%161
10
Bendamustine-hydrochloride8.4%155
11
Oxaliplatin8.4%154
12
Cytarabine7.8%143
13
Prednisolone7.7%142
14
Etoposide6.9%127
15
Tocilizumab6.6%121

Taken alongside

1
Acetaminophen19.7%363
2
Acyclovir18.4%340
3
Dexamethasone18.1%333
4
Allopurinol12.4%228
5
Sulfamethoxazole10.0%184
6
Trimethoprim9.8%180
7
Filgrastim8.2%151
8
Ondansetron7.9%145
9
Pantoprazole-sodium7.3%135
10
Omeprazole7.0%129
11
Methylprednisolone5.7%105
12
Chlorpheniramine5.4%100
13
Enoxaparin-sodium5.0%93
14
Dexchlorpheniramine-maleate4.6%84
15
Furosemide4.2%78

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports glofitamab side effects

31.9% of glofitamab adverse event reports involve female patients and 48.2% involve male patients. The largest age group is elderly at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female31.9%
Male48.2%
Unknown20.0%

Age group

< 20.0%
2–111.0%
12–171.6%
18–6445.4%
65+51.9%

What is glofitamab used for

Conditions and purposes for which patients were taking glofitamab when the adverse event was reported.

Adverse Drug ReactionB-cell Lymphoma RefractoryB-cell LymphomaB-cell Lymphoma RecurrentB-cell Lymphoma RefractoryB-cell Lymphoma Stage IvBurkitt^s LymphomaBurkitt^s Lymphoma RefractoryBurkitt^s Lymphoma Stage ICentral Nervous System LymphomaChemotherapyChronic Lymphocytic LeukaemiaDiffuse Large B-cell LymphomaDiffuse Large B-cell Lymphoma RefractoryDiffuse Large B-cell Lymphoma

Showing 15 of 54 indications

Glofitamab brand names and reporting trend

Glofitamab is sold under the brand name Columvi.

Brand names

Columvi2,334

Quarterly reports (20212025)

2021202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking glofitamab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.