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Glipizide Side Effects

The most commonly reported side effects of glipizide include blood glucose increased, blood glucose increased, and diarrhoea, based on 62,682 FDA adverse event reports from 2004 to 2025. 4.3% of reports found the drug to be ineffective.

Glipizide side effects

Percentages show how often each reaction appears relative to total reports for glipizide.

1
Blood Glucose Increased5.7%3,545
2
Blood Glucose Increased5.5%3,466
3
Drug Ineffective4.3%2,669
4
Diarrhoea4.0%2,537
5
Nausea4.0%2,484
6
Fatigue3.8%2,355
7
Nausea3.5%2,199
8
Death2.8%1,770
9
Chronic Kidney Disease2.7%1,676
10
Dyspnoea2.6%1,639
11
Weight Decreased2.5%1,595
12
Acute Kidney Injury2.5%1,565
13
Dizziness2.5%1,558
14
Off Label Use2.4%1,509
15
Pain2.3%1,434

These are voluntary reports and do not establish that glipizide caused these reactions.

Report severity

56.1%Serious35,183 reports
29.7%Hospitalizations18,602 reports
8.7%Fatal5,459 reports

Seriousness is determined by the reporter, not by OpenClaim.

Glipizide drug interactions

Other drugs that appear in adverse event reports alongside glipizide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Exenatide-synthetic9.2%5,746
2
Metformin6.4%4,037
3
Lenalidomide4.5%2,848
4
Insulin4.5%2,807
5
Dulaglutide3.2%2,014
6
Rosiglitazone-maleate2.8%1,771
7
Adalimumab2.7%1,720
8
Omeprazole2.7%1,683
9
Sitagliptin2.5%1,564
10
Esomeprazole2.4%1,504
11
Pioglitazone-hydrochloride2.3%1,456
12
Pantoprazole-sodium1.6%1,028
13
Pregabalin1.5%950
14
Lansoprazole1.5%936
15
Lisinopril1.4%863

Taken alongside

1
Metformin45.3%28,371
2
Aspirin21.8%13,682
3
Lisinopril18.7%11,699
4
Atorvastatin-calcium17.7%11,110
5
Insulin17.4%10,935
6
Furosemide15.3%9,599
7
Metoprolol14.7%9,242
8
Amlodipine13.0%8,154
9
Simvastatin12.0%7,547
10
Acetaminophen11.9%7,456
11
Levothyroxine-sodium10.9%6,836
12
Gabapentin10.8%6,740
13
Ergocalciferol10.5%6,554
14
Omeprazole10.3%6,441
15
Losartan-potassium9.1%5,689

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports glipizide side effects

48.1% of glipizide adverse event reports involve female patients and 46.2% involve male patients. The largest age group is elderly at 54%. These figures reflect who reports side effects, not underlying risk.

Sex

Female48.1%
Male46.2%
Unknown5.7%

Age group

< 20.2%
2–11<0.1%
12–17<0.1%
18–6446.0%
65+53.8%

What is glipizide used for

Conditions and purposes for which patients were taking glipizide when the adverse event was reported.

Accidental ExposureAccidental Exposure To Product By ChildAccidental PoisoningAdjuvant TherapyAdverse EventAntiviral ProphylaxisAstheniaAccidental Exposure To Product By ChildAnticoagulant TherapyArteriosclerosisAsthmaBack PainBlood Antidiuretic Hormone DecreasedBlood Cholesterol AbnormalBlood Glucose

Showing 15 of 173 indications

Glipizide brand names and reporting trend

Glipizide is sold under the brand name Glucotrol.

Brand names

Glucotrol55,127

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking glipizide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.