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Glimepiride Side Effects

The most commonly reported side effects of glimepiride include blood glucose increased, blood glucose increased, and diarrhoea, based on 61,641 FDA adverse event reports from 2004 to 2025. 3.2% of reports found the drug to be ineffective.

Glimepiride side effects

Percentages show how often each reaction appears relative to total reports for glimepiride.

1
Blood Glucose Increased4.5%2,777
2
Blood Glucose Increased4.4%2,709
3
Diarrhoea3.8%2,367
4
Nausea3.8%2,312
5
Nausea3.2%2,000
6
Drug Ineffective3.2%1,978
7
Fatigue3.2%1,973
8
Hypoglycaemia3.2%1,959
9
Acute Kidney Injury2.5%1,554
10
Weight Decreased2.5%1,517
11
Dyspnoea2.4%1,451
12
Dizziness2.3%1,430
13
Vomiting2.2%1,361
14
Death2.1%1,321
15
Asthenia2.1%1,320

These are voluntary reports and do not establish that glimepiride caused these reactions.

Report severity

67.7%Serious41,747 reports
38.5%Hospitalizations23,724 reports
9.1%Fatal5,635 reports

Seriousness is determined by the reporter, not by OpenClaim.

Glimepiride drug interactions

Other drugs that appear in adverse event reports alongside glimepiride. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Exenatide-synthetic9.3%5,744
2
Metformin9.1%5,612
3
Rosiglitazone-maleate4.8%2,947
4
Insulin4.5%2,765
5
Sitagliptin3.5%2,186
6
Lenalidomide2.8%1,744
7
Pioglitazone-hydrochloride2.7%1,681
8
Dulaglutide2.6%1,611
9
Adalimumab2.2%1,377
10
Omeprazole1.9%1,186
11
Esomeprazole1.7%1,032
12
Aspirin1.6%1,010
13
Pregabalin1.3%828
14
Liraglutide1.3%811
15
Atorvastatin-calcium1.3%797

Taken alongside

1
Metformin38.1%23,511
2
Aspirin19.8%12,184
3
Insulin15.6%9,637
4
Atorvastatin-calcium14.9%9,193
5
Amlodipine13.0%8,016
6
Furosemide12.5%7,730
7
Lisinopril11.8%7,282
8
Metoprolol10.6%6,521
9
Levothyroxine-sodium9.6%5,902
10
Simvastatin9.5%5,839
11
Sitagliptin8.7%5,373
12
Acetaminophen8.6%5,309
13
Omeprazole8.4%5,156
14
Ergocalciferol8.2%5,052
15
Hydrochlorothiazide7.5%4,612

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports glimepiride side effects

46.7% of glimepiride adverse event reports involve female patients and 47.7% involve male patients. The largest age group is elderly at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female46.7%
Male47.7%
Unknown5.5%

Age group

< 2<0.1%
2–11<0.1%
12–17<0.1%
18–6442.9%
65+57.0%

What is glimepiride used for

Conditions and purposes for which patients were taking glimepiride when the adverse event was reported.

Accidental ExposureAccidental Exposure To ProductAccidental Exposure To Product By ChildAccidental PoisoningAcute Myocardial InfarctionAdverse Drug ReactionAdverse EventAngina PectorisArthritisAsthmaAbdominal DistensionAdverse Drug ReactionAnxietyBalance DisorderBipolar Disorder

Showing 15 of 236 indications

Glimepiride brand names and reporting trend

Glimepiride is sold under the brand name Rosiglitazone Maleate And Glimepiride.

Brand names

Rosiglitazone Maleate And Glimepiride40,895

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking glimepiride with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.