OpenClaim

Glecaprevir Side Effects

The most commonly reported side effects of glecaprevir include fatigue, headache, and nausea, based on 10,863 FDA adverse event reports from 2017 to 2025. 1.7% of reports found the drug to be ineffective.

Glecaprevir side effects

Percentages show how often each reaction appears relative to total reports for glecaprevir.

1
Fatigue23.7%2,570
2
Headache20.3%2,210
3
Nausea10.4%1,130
4
Pruritus6.1%659
5
Diarrhoea4.4%481
6
Rash2.9%314
7
Vomiting2.9%310
8
Dizziness2.1%232
9
Death2.0%222
10
Pain1.9%209
11
Insomnia1.9%205
12
Abdominal Discomfort1.8%197
13
Drug Ineffective1.7%180
14
Asthenia1.5%160
15
Abdominal Pain Upper1.4%150

These are voluntary reports and do not establish that glecaprevir caused these reactions.

Report severity

25.7%Serious2,793 reports
12.1%Hospitalizations1,311 reports
2.7%Fatal290 reports

Seriousness is determined by the reporter, not by OpenClaim.

Glecaprevir drug interactions

Other drugs that appear in adverse event reports alongside glecaprevir. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Pibrentasvir98.3%10,682
2
Sofosbuvir0.6%61
3
Velpatasvir0.3%37
4
Lisinopril0.2%22
5
Ledipasvir0.2%22
6
Tenofovir0.2%21
7
Ribavirin0.2%18
8
Tacrolimus0.2%18
9
Emtricitabine0.2%18
10
Grazoprevir0.1%12
11
Buprenorphine0.1%11
12
Elbasvir0.1%11
13
Voxilaprevir<0.1%10
14
Efavirenz<0.1%10
15
Simvastatin<0.1%9

Taken alongside

1
Gabapentin2.7%293
2
Aspirin2.5%270
3
Albuterol2.5%268
4
Amlodipine2.5%268
5
Lisinopril2.3%254
6
Omeprazole2.0%217
7
Acetaminophen1.9%203
8
Ibuprofen1.8%192
9
Ergocalciferol1.7%182
10
Metoprolol1.7%180
11
Furosemide1.6%171
12
Pantoprazole-sodium1.5%166
13
Pibrentasvir1.5%164
14
Buprenorphine1.3%141
15
Insulin1.2%131

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports glecaprevir side effects

43.6% of glecaprevir adverse event reports involve female patients and 49.1% involve male patients. The largest age group is adult at 85%. These figures reflect who reports side effects, not underlying risk.

Sex

Female43.6%
Male49.1%
Unknown7.4%

Age group

< 2<0.1%
2–11<0.1%
12–17<0.1%
18–6484.7%
65+15.1%

What is glecaprevir used for

Conditions and purposes for which patients were taking glecaprevir when the adverse event was reported.

Acute Hepatitis BAcute Hepatitis CAntiviral ProphylaxisAcute Hepatitis CAntiretroviral TherapyAntiviral Drug LevelAntiviral ProphylaxisAttention Deficit Hyperactivity DisorderBipolar DisorderBreast CancerChild-pugh-turcotte ScoreChild-pugh-turcotte Score IncreasedChronic HepatitisChronic Hepatitis CChronic Kidney Disease

Showing 15 of 76 indications

Glecaprevir brand names and reporting trend

Glecaprevir is sold under the brand name Mavyret.

Brand names

Mavyret58

Quarterly reports (20172025)

20182020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking glecaprevir with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.