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Glatiramer Side Effects

The most commonly reported side effects of glatiramer include injection site pain, multiple sclerosis relapse, and injection site reaction, based on 62,243 FDA adverse event reports from 2004 to 2025. 6.5% of reports found the drug to be ineffective.

Glatiramer side effects

Percentages show how often each reaction appears relative to total reports for glatiramer.

1
Injection Site Pain8.4%5,215
2
Multiple Sclerosis Relapse7.5%4,688
3
Drug Ineffective6.5%4,021
4
Injection Site Reaction5.5%3,439
5
Fatigue5.2%3,235
6
Multiple Sclerosis4.9%3,026
7
Dyspnoea4.2%2,635
8
Injection Site Erythema4.1%2,573
9
Fall4.0%2,479
10
Injection Site Mass3.6%2,236
11
Gait Disturbance3.3%2,037
12
Pain3.2%1,974
13
Dizziness3.0%1,844
14
Nausea2.9%1,835
15
Injection Site Swelling2.9%1,812

These are voluntary reports and do not establish that glatiramer caused these reactions.

Report severity

46.8%Serious29,117 reports
15.7%Hospitalizations9,799 reports
2.1%Fatal1,325 reports

Seriousness is determined by the reporter, not by OpenClaim.

Glatiramer drug interactions

Other drugs that appear in adverse event reports alongside glatiramer. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dalfampridine7.5%4,682
2
Interferon3.2%2,017
3
Dimethyl2.0%1,271
4
Natalizumab1.9%1,191
5
Fingolimod1.4%884
6
Teriflunomide1.2%749
7
Ocrelizumab1.1%662
8
Methylprednisolone0.4%248
9
Tizanidine-hydrochloride0.3%203
10
Baclofen0.3%186
11
Peginterferon0.3%176
12
Gabapentin0.3%158
13
Pregabalin0.3%157
14
Rituximab0.2%149
15
Alemtuzumab0.2%126

Taken alongside

1
Ergocalciferol7.2%4,478
2
Baclofen4.8%2,969
3
Gabapentin4.7%2,901
4
Acetaminophen2.9%1,800
5
Levothyroxine-sodium2.8%1,747
6
Aspirin2.1%1,314
7
Omeprazole2.0%1,273
8
Cyanocobalamin2.0%1,240
9
Interferon1.9%1,206
10
Ibuprofen1.9%1,173
11
Duloxetine-hydrochloride1.7%1,062
12
Lisinopril1.7%1,034
13
Atorvastatin-calcium1.6%993
14
Clonazepam1.5%961
15
Calcium1.5%960

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports glatiramer side effects

76.0% of glatiramer adverse event reports involve female patients and 18.5% involve male patients. The largest age group is adult at 87%. These figures reflect who reports side effects, not underlying risk.

Sex

Female76.0%
Male18.5%
Unknown5.4%

Age group

< 20.5%
2–110.1%
12–170.5%
18–6487.3%
65+11.5%

What is glatiramer used for

Conditions and purposes for which patients were taking glatiramer when the adverse event was reported.

Abdominal InfectionAbdominal Pain UpperAcquired Pyrimidine Metabolism DisorderAdverse ReactionAmyotrophic Lateral SclerosisAnaemiaAnaphylactic ReactionAnkylosing SpondylitisAnxiety DisorderArteriosclerosisAttention Deficit/hyperactivity DisorderAutoimmune ThyroiditisAngiogramAnkylosing SpondylitisArthritis

Showing 15 of 211 indications

Glatiramer brand names and reporting trend

Glatiramer is sold under the brand name Copaxone.

Brand names

Copaxone7,292

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking glatiramer with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.