OpenClaim

Gentian Side Effects

The most commonly reported side effects of gentian include nausea, off label use, and condition aggravated, based on 71 FDA adverse event reports from 2004 to 2025. 15.5% of reports found the drug to be ineffective.

Gentian side effects

Percentages show how often each reaction appears relative to total reports for gentian.

1
Drug Ineffective15.5%11
2
Nausea11.3%8
3
Off Label Use9.9%7
4
Condition Aggravated8.5%6
5
Dizziness8.5%6
6
Treatment Failure8.5%6
7
Therapeutic Product Effect Incomplete8.5%6
8
Fatigue7.0%5
9
Dyspnoea7.0%5
10
Fall5.6%4
11
Hypotension5.6%4
12
Erythema5.6%4
13
Contusion5.6%4
14
Headache5.6%4
15
Nasopharyngitis5.6%4

These are voluntary reports and do not establish that gentian caused these reactions.

Report severity

73.2%Serious52 reports
36.6%Hospitalizations26 reports
9.9%Fatal7 reports

Seriousness is determined by the reporter, not by OpenClaim.

Gentian drug interactions

Other drugs that appear in adverse event reports alongside gentian. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sodium-oxybate9.9%7
2
Lenalidomide7.0%5
3
Clarithromycin7.0%5
4
Terbinafine7.0%5
5
Chlorhexidine-gluconate7.0%5
6
Amphotericin-b5.6%4
7
Voriconazole5.6%4
8
Neomycin-sulfate4.2%3
9
Certolizumab-pegol4.2%3
10
Adalimumab4.2%3
11
Celecoxib4.2%3
12
Tocilizumab4.2%3
13
Amifostine2.8%2
14
Bacitracin2.8%2
15
Hydrocortisone2.8%2

Taken alongside

1
Acetaminophen21.1%15
2
Ibuprofen18.3%13
3
Albuterol18.3%13
4
Ergocalciferol18.3%13
5
Oxycodone15.5%11
6
Lidocaine12.7%9
7
Aspirin12.7%9
8
Furosemide12.7%9
9
Atorvastatin-calcium11.3%8
10
Celecoxib11.3%8
11
Levothyroxine-sodium11.3%8
12
Chlorhexidine-gluconate9.9%7
13
Fluticasone9.9%7
14
Mirtazapine9.9%7
15
Clindamycin9.9%7

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports gentian side effects

52.1% of gentian adverse event reports involve female patients and 43.7% involve male patients. The largest age group is adult at 61%. These figures reflect who reports side effects, not underlying risk.

Sex

Female52.1%
Male43.7%
Unknown4.2%

Age group

< 22.0%
2–1111.8%
12–170.0%
18–6460.8%
65+25.5%

What is gentian used for

Conditions and purposes for which patients were taking gentian when the adverse event was reported.

Antifungal TreatmentCandida InfectionEar InfectionEar PruritusFungal InfectionFungal Skin InfectionFusarium InfectionGastritisGastritis ProphylaxisHelminthic InfectionOral CandidiasisOral PainProduct Used For Unknown IndicationProduct Used For Unknown IndicationScrotal Erythema

Showing 15 of 18 indications

Gentian brand names and reporting trend

Gentian is sold under the brand name Genapax.

Brand names

Genapax76

Quarterly reports (20042025)

200420202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking gentian with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.